This is a small case series of patients with refractory...
George Ferman@Helios_Movement
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Oct 26, 2026
~1 min read
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This is a small case series of patients with refractory neuropsychiatric disorders such as depression, anxiety, OCD, ADHD and more, who experienced significant improvement after subsequent diagnosis and treatment of MCAS.
While the average person still thinks that histamine for example is just something related to allergies, let’s not forget that histamine acts as a neurotransmitter in the brain, influencing things such as arousal, attention, mood, sleep, and motivation.
So when levels build up it can create:
-Restlessness and physical + mental hyperactivity
-Difficulty concentrating, brain fog, inattention
-Irritability, impulsivity, or agitation
-Sleep disturbances (insomnia or poor sleep quality)
-Anxiety or sensory sensitivities
-Hyper arousal
-Racing thoughts, anxiety/panic, or restlessness
-Insomnia or disrupted sleep cycles (common in manic phases)
-Depressive symptoms (fatigue, brain fog, low motivation) during crashes
-Emotional lability or energy fluctuations
Of course, we don’t pull all these out of our asses.
There are more reports noting that histamine flares can mimic manic/depressive episodes, and MCAS patients sometimes receive initial bipolar diagnoses.
While the average person still thinks that histamine for example is just something related to allergies, let’s not forget that histamine acts as a neurotransmitter in the brain, influencing things such as arousal, attention, mood, sleep, and motivation.
So when levels build up it can create:
-Restlessness and physical + mental hyperactivity
-Difficulty concentrating, brain fog, inattention
-Irritability, impulsivity, or agitation
-Sleep disturbances (insomnia or poor sleep quality)
-Anxiety or sensory sensitivities
-Hyper arousal
-Racing thoughts, anxiety/panic, or restlessness
-Insomnia or disrupted sleep cycles (common in manic phases)
-Depressive symptoms (fatigue, brain fog, low motivation) during crashes
-Emotional lability or energy fluctuations
Of course, we don’t pull all these out of our asses.
There are more reports noting that histamine flares can mimic manic/depressive episodes, and MCAS patients sometimes receive initial bipolar diagnoses.
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Learn more about the brain:
fitandball.gumroad.com/l/brain20/v30
fitandball.gumroad.com/l/brain20/v30
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Read:
George Ferman@Helios_Movement
Maybe your IBS is actually MCAS,
After all, H1 and H2 histamine receptors are overexpressed and upregulated in IBS patients and plenty of times there are also elevated mucosal mast cells.
So when these local mast cells activate, they release substances that alter gut motility, increase intestinal permeability, and trigger pain sensors.
In general, histamine intolerance or even MCAS are common issues, yet still quite unaddressed for people with chronic gut issues.
But most of the advice barely scratches the surface.
Let's change that.
Thread🧵
After all, H1 and H2 histamine receptors are overexpressed and upregulated in IBS patients and plenty of times there are also elevated mucosal mast cells.
So when these local mast cells activate, they release substances that alter gut motility, increase intestinal permeability, and trigger pain sensors.
In general, histamine intolerance or even MCAS are common issues, yet still quite unaddressed for people with chronic gut issues.
But most of the advice barely scratches the surface.
Let's change that.
Thread🧵