@Outdoctrination: Aspirin was recently shown to ...
@Outdoctrination
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Jan 02, 2026
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Aspirin was recently shown to reduce liver fat by nearly 40% in a recent landmark study.
(🧵1/7)
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This study was published early last year in JAMA.
They examined the response of people with fatty liver disease (now called "metabolic dysfunction-associated steatohepatitis") to aspirin.
They took a baby aspirin (81 mg) daily.
They examined the response of people with fatty liver disease (now called "metabolic dysfunction-associated steatohepatitis") to aspirin.
They took a baby aspirin (81 mg) daily.
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People were randomized to either aspirin or placebo.
This type of study design minimizes confounding factors and allows us to see true effects of aspirin on its own.
71 people made it to the end of the trial (6 months).
This type of study design minimizes confounding factors and allows us to see true effects of aspirin on its own.
71 people made it to the end of the trial (6 months).
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Aspirin had a stunning impact on every metric of liver health examined.
Hepatic fat by magnetic resonance spectroscopy decreased from 39.1% → 32.0% with aspirin,
meanwhile it INCREASED from 31.2% → 35.4% in placebo.
That is a 38.8% relative decrease in liver fat with taking aspirin.
42.5% of people on aspirin achieved a reduction of >30% fat.
Hepatic fat by magnetic resonance spectroscopy decreased from 39.1% → 32.0% with aspirin,
meanwhile it INCREASED from 31.2% → 35.4% in placebo.
That is a 38.8% relative decrease in liver fat with taking aspirin.
42.5% of people on aspirin achieved a reduction of >30% fat.
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People taking aspirin also had substantial improvements in liver inflammation / fibrosis.
• ALT (IU/L): 53.1 → 37.2
• AST (IU/L): 40.5 → 26.0 (both markers of liver damage)
• Iron-corrected T1 (ms): 898.8 → 876.0
• Liver stiffness by VCTE (kPa): 7.1 → 6.0 (measures of liver fibrosis)
This is huge - the inflammation and fibrosis is what really causes the issues.
• ALT (IU/L): 53.1 → 37.2
• AST (IU/L): 40.5 → 26.0 (both markers of liver damage)
• Iron-corrected T1 (ms): 898.8 → 876.0
• Liver stiffness by VCTE (kPa): 7.1 → 6.0 (measures of liver fibrosis)
This is huge - the inflammation and fibrosis is what really causes the issues.
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Now how exactly was aspirin able to do this?
Yes, it's an anti-inflammatory, but aspirin seems to have some unique qualities that allow it to help the liver shed fat.
A previous study showed that platelets, which help form blood clots, actually infiltrate the liver early on in fatty liver disease.
When these platelets are activated, they attach to the liver and drive a greater immune response, which results in:
◇ More inflammation
◇ More immune cells
◇ More fibrosis
◇ Less fat oxidation
◇ More fat production
Aspirin is a platelet activation inhibitor.
Yes, it's an anti-inflammatory, but aspirin seems to have some unique qualities that allow it to help the liver shed fat.
A previous study showed that platelets, which help form blood clots, actually infiltrate the liver early on in fatty liver disease.
When these platelets are activated, they attach to the liver and drive a greater immune response, which results in:
◇ More inflammation
◇ More immune cells
◇ More fibrosis
◇ Less fat oxidation
◇ More fat production
Aspirin is a platelet activation inhibitor.
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Another study looked at aspirin's ability to change the molecular biology within the liver.
They showed that, after being insulted with fat and cholesterol, aspirin:
◈ Increased PPARδ (improves fat burning, reduces inflammation)
◈ Ups AMPK (increases metabolic activity)
◈ Reduces NF-κB (master inflammation regulator)
◈ Suppresses FAS (fat production enzyme)
◈ Improves ATP and oxygen consumption
They showed that, after being insulted with fat and cholesterol, aspirin:
◈ Increased PPARδ (improves fat burning, reduces inflammation)
◈ Ups AMPK (increases metabolic activity)
◈ Reduces NF-κB (master inflammation regulator)
◈ Suppresses FAS (fat production enzyme)
◈ Improves ATP and oxygen consumption
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This is the aspirin powder we typically use, totally additive free and comes in a scoop the size of a baby aspirin.
Refer to the linked thread above for more on how to use / the benefits of aspirin. healthnatura.com/aspirin-powder…
Refer to the linked thread above for more on how to use / the benefits of aspirin. healthnatura.com/aspirin-powder…
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Aspirin is very useful, but of course if you have fatty liver or any other condition, you'll want to address it at the root cause with a comprehensive approach.
If you're interested in that and want some help from us - book a free call here: go.prism.miami/consultation
If you're interested in that and want some help from us - book a free call here: go.prism.miami/consultation