Pregnenolone is my absolute favorite supplement of all time. Its...
Dalton (Analyze & Optimize)@Outdoctrination
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May 12, 2025
~5 min read
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Pregnenolone is my absolute favorite supplement of all time.
Its ability to improve mood, lower stress, reduce fatigue and enhance cognition is second to none.
I literally feel invincible with it.
Let's get into the science of why it's so incredible and how to use it:
Its ability to improve mood, lower stress, reduce fatigue and enhance cognition is second to none.
I literally feel invincible with it.
Let's get into the science of why it's so incredible and how to use it:
Dalton (Analyze & Optimize)@Outdoctrination
PREGNENOLONE: The closest you’ll get to the fountain of youth.
This protective hormone’s anti-aging properties, and how it bulletproofs your mitochondria and energy.
This protective hormone’s anti-aging properties, and how it bulletproofs your mitochondria and energy.
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Pregnenolone is a powerful antidepressant.
100 mg a day has been shown to reduce both depression and mania.
This has absolutely been my experience, an incredible mood stabilizer.
100 mg a day has been shown to reduce both depression and mania.
This has absolutely been my experience, an incredible mood stabilizer.
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Pregnenolone prevents fatigue.
In the 40s-50s pregnenolone was tested for performance in army pilots.
It was shown that 57 mg prevents mental fatigue even after hours of operating a plane.
This is true in my experience as well, you can roll through mental tasks seamlessly.
In the 40s-50s pregnenolone was tested for performance in army pilots.
It was shown that 57 mg prevents mental fatigue even after hours of operating a plane.
This is true in my experience as well, you can roll through mental tasks seamlessly.
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Pregnenolone is a steroid of youth.
Neurosteroids like pregnenolone decline precipitously with age.
So does mood, memory, and resilience.
Supplying these youth compounds back can help you turn back the clock.
Neurosteroids like pregnenolone decline precipitously with age.
So does mood, memory, and resilience.
Supplying these youth compounds back can help you turn back the clock.
Dalton (Analyze & Optimize)@Outdoctrination
DHEA: a fountain of youth.
For lowering cortisol, improving cognitive function & mood, vibrant skin and fat loss, it might be just what you need.
Here’s why researchers have called aging “DHEA deficiency syndrome:”
For lowering cortisol, improving cognitive function & mood, vibrant skin and fat loss, it might be just what you need.
Here’s why researchers have called aging “DHEA deficiency syndrome:”
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Depression is low pregnenolone in disguise.
Pregnenolone levels plummet by nearly HALF in depression.
The worse the mood disorder, lower the levels.
This is because pregnenolone has tons of protective actions on the brain.
Pregnenolone levels plummet by nearly HALF in depression.
The worse the mood disorder, lower the levels.
This is because pregnenolone has tons of protective actions on the brain.
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Social anxiety is a low pregnenolone state.
In generalized anxiety, levels of pregnenolone sulfate and allopregnanolone, two key metabolites of pregnenolone, are as much as 70% lower than normal.
This is another thing I have noticed it improves from using it personally.
In generalized anxiety, levels of pregnenolone sulfate and allopregnanolone, two key metabolites of pregnenolone, are as much as 70% lower than normal.
This is another thing I have noticed it improves from using it personally.
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Pregnenolone reduces negative thought patterns.
✓ Reduced activity in "emotional" brain regions
✓ Increased activity in the higher thinking regions
✓ Increased connectivity between higher thinking / emotion
I struggled with this a lot, pregnenolone was a huge help.
✓ Reduced activity in "emotional" brain regions
✓ Increased activity in the higher thinking regions
✓ Increased connectivity between higher thinking / emotion
I struggled with this a lot, pregnenolone was a huge help.
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Pregnenolone improves negative mood.
50 mg.
Negative symptoms = absent or diminished normal functions.
◇ Blunted affect (reduced emotional expression)
◇ Anhedonia (inability to feel pleasure)
◇ Avolition (lack of motivation)
Normally from low dopamine.
50 mg.
Negative symptoms = absent or diminished normal functions.
◇ Blunted affect (reduced emotional expression)
◇ Anhedonia (inability to feel pleasure)
◇ Avolition (lack of motivation)
Normally from low dopamine.
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Pregnenolone is a powerful anti-inflammatory.
Stops neuroinflammation at the root by:
· Degrading TLR2/4 adapter proteins
· Suppressing microglial activation
· Lowering TNFα and IL-6
Every mental + cognitive disorder is characterized by neuroinflammation.
Pregnenolone helps.
Stops neuroinflammation at the root by:
· Degrading TLR2/4 adapter proteins
· Suppressing microglial activation
· Lowering TNFα and IL-6
Every mental + cognitive disorder is characterized by neuroinflammation.
Pregnenolone helps.
Dalton (Analyze & Optimize)@Outdoctrination
Depression is inflammation in disguise.
Inflammatory markers are higher across the board, sometimes by 2-3X, in depressed people.
Anti-inflammatories:
• Aspirin
• Taurine
• Pregnenolone/progesterone
• Red light
• Glycine
etc
should be explored.
Inflammatory markers are higher across the board, sometimes by 2-3X, in depressed people.
Anti-inflammatories:
• Aspirin
• Taurine
• Pregnenolone/progesterone
• Red light
• Glycine
etc
should be explored.
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Low doses of pregnenolone increase deep, restorative sleep.
Just 1 mg of pregnenolone boosts delta wave (slow wave) activity.
This is the deepest type of sleep and most people struggle to get into it regularly.
Pregnenolone helps.
Just 1 mg of pregnenolone boosts delta wave (slow wave) activity.
This is the deepest type of sleep and most people struggle to get into it regularly.
Pregnenolone helps.
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Pregnenolone helps regenerate brain cells.
It's been shown to increase BDNF production in multiple brain regions, a protein that stimulates:
➔ Nerve growth
➔ Proliferation
➔ Survival
BDNF levels are low in every mental + cognitive disorder.
It's been shown to increase BDNF production in multiple brain regions, a protein that stimulates:
➔ Nerve growth
➔ Proliferation
➔ Survival
BDNF levels are low in every mental + cognitive disorder.
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Pregnenolone improves memory + learning, stimulates synaptic plasticity,
It enhances a process called long-term potentiation.
Essentially, this makes neural pathways in the brain more robust over time.
Pregnenolone also boosts dopamine, vital for motivation and reward.
It enhances a process called long-term potentiation.
Essentially, this makes neural pathways in the brain more robust over time.
Pregnenolone also boosts dopamine, vital for motivation and reward.
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Pregnenolone prevents brain cell death from Alzheimer's plaques.
Pregnenolone is often depleted in cognitive decline, and this is one of its main neuroprotective actions.
I've gone in deeper to the Alzheimer's story below.
Pregnenolone is often depleted in cognitive decline, and this is one of its main neuroprotective actions.
I've gone in deeper to the Alzheimer's story below.
Dalton (Analyze & Optimize)@Outdoctrination
Alzheimer's prevalence is set to double in the next 25 years.
Yet, mainstream treatments have been complete and utter failures.
Probably because they don't fundamentally understand the problem.
Here's what really behind it, and what you might be able to do about it:
Yet, mainstream treatments have been complete and utter failures.
Probably because they don't fundamentally understand the problem.
Here's what really behind it, and what you might be able to do about it:
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Pregnenolone also protects brain cells against glutamate excitotoxicity.
This is a process where neurons can fry themselves out under loads of stress, since glutamate is the "excitatory" neurotransmitter.
Conditions driven by excess glutamate in the brain:
◇ ADHD
◇ Anxiety
◇ Depression
◇ Autism
This is a process where neurons can fry themselves out under loads of stress, since glutamate is the "excitatory" neurotransmitter.
Conditions driven by excess glutamate in the brain:
◇ ADHD
◇ Anxiety
◇ Depression
◇ Autism
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Pregnenolone metabolite (allopregnanolone) revives the decaying brain.
• Decreases hippocampal (brain region) volume loss
• Promotes myelination
• Increases neuron fiber density
• Increases brain connectivity
in Alzheimer's.
Achievable with 20+ mg doses oral pregnenolone
• Decreases hippocampal (brain region) volume loss
• Promotes myelination
• Increases neuron fiber density
• Increases brain connectivity
in Alzheimer's.
Achievable with 20+ mg doses oral pregnenolone
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Pregnenolone literally protects the brain.
During stroke, it reduces the size of the injury to the brain, an incredibly powerful property.
· Shrinks infarct size
· Reverses cognitive deficits
· Improves mitochondria
· Lowers oxidative stress
Nuts.
During stroke, it reduces the size of the injury to the brain, an incredibly powerful property.
· Shrinks infarct size
· Reverses cognitive deficits
· Improves mitochondria
· Lowers oxidative stress
Nuts.
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Weed impairs dopamine function - pregnenolone restores it.
Cannabis is known to have detrimental effects on the dopamine system, especially for developing brains.
Pregnenolone rescues this, in part because it blocks the cannabinoid receptor (1).
More on that whole issue below.
Cannabis is known to have detrimental effects on the dopamine system, especially for developing brains.
Pregnenolone rescues this, in part because it blocks the cannabinoid receptor (1).
More on that whole issue below.
Dalton (Analyze & Optimize)@Outdoctrination
Time to come back to reality. Smoking weed is NOT harmless.
It literally shrinks your brain, drops your IQ, and might even cause cancer.
Let’s talk about it:
It literally shrinks your brain, drops your IQ, and might even cause cancer.
Let’s talk about it:
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This is the only pregnenolone I use, other brands have just never hit in my experience.
Been using for years at this point.
healthnatura.com/pregnenolone-2…
Been using for years at this point.
healthnatura.com/pregnenolone-2…
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Most studies look at pregnenolone 50-500 mg. I think starting on the lower end there and seeing how it goes is your best bet.
If you're prone to estrogenic overload then definitely want to be more careful since it can convert to estrogen (though it is functionally anti-estrogen).
Otherwise, very very safe. I've taken up to 2g in periods of very high stress and felt nothing but level headed calmness.
If you're prone to estrogenic overload then definitely want to be more careful since it can convert to estrogen (though it is functionally anti-estrogen).
Otherwise, very very safe. I've taken up to 2g in periods of very high stress and felt nothing but level headed calmness.
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Pregnenolone is incredible, but it will likely only be a part of your journey to optimal health.
If YOU want personalized help from us with your health, schedule a free call here: prism.miami/scheduling
If YOU want personalized help from us with your health, schedule a free call here: prism.miami/scheduling
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Thank you for reading through this. Give this tweet below a repost if you found it interesting to spread the message.
Dalton (Analyze & Optimize)@Outdoctrination
Pregnenolone is my absolute favorite supplement of all time.
Its ability to improve mood, lower stress, reduce fatigue and enhance cognition is second to none.
I literally feel invincible with it.
Let's get into the science of why it's so incredible and how to use it:
Its ability to improve mood, lower stress, reduce fatigue and enhance cognition is second to none.
I literally feel invincible with it.
Let's get into the science of why it's so incredible and how to use it:
22
Be sure to check out all of our content, supplements, lab testing options and join our email list for exclusive offers here: analyzeandoptimize.io
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SOURCES
pubmed.ncbi.nlm.nih.gov/20493557/ 100 mg improves depression, mania
pubmed.ncbi.nlm.nih.gov/8395958/sci-hub.se/10.1016/0006-8… low dose pregnenolone increases deep (delta wave) sleep
asma.kglmeridian.com/meridian/asma/… 57 mg prevents fatigue + increases performance after long hours in operating a plane
pmc.ncbi.nlm.nih.gov/articles/PMC23… pregnenolone + other steroids decline w age
biologicalpsychiatryjournal.com/article/0006-3… pregnenolone decreases w worsening mood state - about half in depression
sci-hub.se/10.1017/s00332… preg sulfate about half as much in those w social phobia. anxiety - a third of the pregS + alloP v control
jbc.org/article/S0021-… degrades TLR2, TLR2/4 adapter proteins, suppress TNFa and IL-6 in microglia. This is very important for preventing every mental and cognitive disorder
sci-hub.se/10.1016/j.psyn… increases BDNF
pmc.ncbi.nlm.nih.gov/articles/PMC46… increases plasticity (long term potentiation) + dopamine, this increases cognitive performance and memory
sci-hub.se/10.1016/j.cbi.… decreases neuron death from amyloid
sci-hub.se/10.1023/a:1007… Protects neurons from glutamate excitotoxicity
x.com/Outdoctrinatio… alz
x.com/Outdoctrinatio… negative thoughts
social skills
pmc.ncbi.nlm.nih.gov/articles/PMC92… reduces infarct size from stroke, reverses cognitive deficits, lowers oxidative stress, improves mitochondrial dysfunction
sci-hub.se/10.1038/s41593… weed causes dopamine dysfunction - preg reverses it
pubmed.ncbi.nlm.nih.gov/20493557/ 100 mg improves depression, mania
pubmed.ncbi.nlm.nih.gov/8395958/sci-hub.se/10.1016/0006-8… low dose pregnenolone increases deep (delta wave) sleep
asma.kglmeridian.com/meridian/asma/… 57 mg prevents fatigue + increases performance after long hours in operating a plane
pmc.ncbi.nlm.nih.gov/articles/PMC23… pregnenolone + other steroids decline w age
biologicalpsychiatryjournal.com/article/0006-3… pregnenolone decreases w worsening mood state - about half in depression
sci-hub.se/10.1017/s00332… preg sulfate about half as much in those w social phobia. anxiety - a third of the pregS + alloP v control
jbc.org/article/S0021-… degrades TLR2, TLR2/4 adapter proteins, suppress TNFa and IL-6 in microglia. This is very important for preventing every mental and cognitive disorder
sci-hub.se/10.1016/j.psyn… increases BDNF
pmc.ncbi.nlm.nih.gov/articles/PMC46… increases plasticity (long term potentiation) + dopamine, this increases cognitive performance and memory
sci-hub.se/10.1016/j.cbi.… decreases neuron death from amyloid
sci-hub.se/10.1023/a:1007… Protects neurons from glutamate excitotoxicity
x.com/Outdoctrinatio… alz
x.com/Outdoctrinatio… negative thoughts
social skills
pmc.ncbi.nlm.nih.gov/articles/PMC92… reduces infarct size from stroke, reverses cognitive deficits, lowers oxidative stress, improves mitochondrial dysfunction
sci-hub.se/10.1038/s41593… weed causes dopamine dysfunction - preg reverses it
Dalton (Analyze & Optimize)@Outdoctrination
Pregnenolone enhances social skills.
Adding 50 mg of pregnenolone DECREASED:
◌ The inability to feel pleasure
◌ Social withdrawal
◌ Emotional withdrawal
◌ Aversion to engage in purposeful activities
◌ Poor rapport
◌ Stereotyped thinking
by growing and calming the brain.
Adding 50 mg of pregnenolone DECREASED:
◌ The inability to feel pleasure
◌ Social withdrawal
◌ Emotional withdrawal
◌ Aversion to engage in purposeful activities
◌ Poor rapport
◌ Stereotyped thinking
by growing and calming the brain.
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If YOU want personalized help from us with your health, schedule a free call here: prism.miami/scheduling