@Outdoctrination: 40% of people have this, and m...
@Outdoctrination
63 views
Feb 05, 2025
1
40% of people have this, and most don't even know it.
This is a fatty liver, and you can have it even if you're skinny.
If you do nothing about it, it can kill you.
Here's how it happens, and what to do to fix it:
This is a fatty liver, and you can have it even if you're skinny.
If you do nothing about it, it can kill you.
Here's how it happens, and what to do to fix it:
2
The liver is the body's central hub for metabolism, including that of fat.
The problems arise when the liver has more fat than it can deal with.
There are 3 sources of fat the liver deals with:
1. Fat from the diet
2. Fat it makes from carbs
3. Free fatty acids from the fat tissue
There are 2 ways the liver can get rid of fat:
1. Burn it for energy
2. Send it back into the blood for other organs
If you have more of the first 3 than the second 2, you get a fatty liver. Pretty simple - it's an imbalance of fat metabolism in the liver.
But what actually causes this imbalance?
The problems arise when the liver has more fat than it can deal with.
There are 3 sources of fat the liver deals with:
1. Fat from the diet
2. Fat it makes from carbs
3. Free fatty acids from the fat tissue
There are 2 ways the liver can get rid of fat:
1. Burn it for energy
2. Send it back into the blood for other organs
If you have more of the first 3 than the second 2, you get a fatty liver. Pretty simple - it's an imbalance of fat metabolism in the liver.
But what actually causes this imbalance?
3
The VAST MAJORITY of fat in fatty liver disease is FREE FATTY ACIDS (or non-esterified fatty acids, NEFA).
These fatty acids are released from the fat tissue during:
◇ Stress
◇ Infection
◇ Insulin resistance
◇ Low carb intake
and get taken up by the liver.
These fatty acids are released from the fat tissue during:
◇ Stress
◇ Infection
◇ Insulin resistance
◇ Low carb intake
and get taken up by the liver.
4
Since most liver fat comes from the fat tissue, and that gets released during stress,
lowering stress is absolutely vital for solving fatty liver disease.
Below is my masterclass on reducing stress.
lowering stress is absolutely vital for solving fatty liver disease.
Below is my masterclass on reducing stress.
View Tweet
5
Inflammation drives liver fat production.
Your liver does make fat from carbs, but:
1. This is normally a negligible portion (5-10%) of the fat in the liver
2. Inflammation is what causes MORE fat to be produced from carbs.
Specifically, inflammation from bacteria in the gut.
Your liver does make fat from carbs, but:
1. This is normally a negligible portion (5-10%) of the fat in the liver
2. Inflammation is what causes MORE fat to be produced from carbs.
Specifically, inflammation from bacteria in the gut.
6
Probiotics reverse fatty liver disease in 50% of people.
Because the gut is such a key chronic source of inflammation, using Lacto/Bifido probiotics can actually reduce liver fat.
Probiotics can reduce the systemic inflammation ("leaky gut") from gut bacteria.
Because the gut is such a key chronic source of inflammation, using Lacto/Bifido probiotics can actually reduce liver fat.
Probiotics can reduce the systemic inflammation ("leaky gut") from gut bacteria.
7
Optimizing gut function is also a top priority when it comes to fixing fatty liver.
If you haven't checked out our master gut thread below, you ought to.
If you haven't checked out our master gut thread below, you ought to.
View Tweet
8
Serotonin causes fatty liver disease.
Serotonin is produced in the gut in response to inflammatory / irritating stimuli.
It gets released into the blood where it drives:
◈ Obesity
◈ Insulin resistance
◈ Inflammation
◈ Fatty liver
A lot of fatty liver starts in the gut.
Serotonin is produced in the gut in response to inflammatory / irritating stimuli.
It gets released into the blood where it drives:
◈ Obesity
◈ Insulin resistance
◈ Inflammation
◈ Fatty liver
A lot of fatty liver starts in the gut.
9
More on serotonin and the gut here:
View Tweet
10
Cortisol drives liver fat production.
Once again we see that dietary carbs are not necessarily the enemy,
but the underlying state of the body can start turning carbs into fat more.
There's actually a condition called glucocorticoid induced fatty liver for this reason.
Once again we see that dietary carbs are not necessarily the enemy,
but the underlying state of the body can start turning carbs into fat more.
There's actually a condition called glucocorticoid induced fatty liver for this reason.
11
Oxidative stress is a primary cause of fatty liver disease.
The liver cannot export fat properly with sufficient oxidative stress.
This keeps fat in the liver.
Here, the enzyme superoxide dismutase (SOD) is shown to play an indispensable role in fat secretion from the liver.
The liver cannot export fat properly with sufficient oxidative stress.
This keeps fat in the liver.
Here, the enzyme superoxide dismutase (SOD) is shown to play an indispensable role in fat secretion from the liver.
12
Superoxide dismutase is dependent on both copper and zinc.
Most of us are OK on copper, but low on zinc, which can lead to oxidative stress and thus fatty liver.
I've written at length about the importance of zinc here, as well as how to get enough:
Most of us are OK on copper, but low on zinc, which can lead to oxidative stress and thus fatty liver.
I've written at length about the importance of zinc here, as well as how to get enough:
View Tweet
13
Autophagy protects against fatty liver.
Superoxide dismutase was also shown to be vital for lipophagy - the process by which cells degrade fat properly so they can burn it.
Without lipophagy, the liver's capacity to burn fat is impaired.
Superoxide dismutase was also shown to be vital for lipophagy - the process by which cells degrade fat properly so they can burn it.
Without lipophagy, the liver's capacity to burn fat is impaired.
14
Caffeine reverses fatty liver disease... by inducing autophagy.
Caffeine is probably the most protective thing for your liver imaginable.
It helps the liver shed its fat very effectively, and this is partially because it helps induce lipophagy.
Caffeine is probably the most protective thing for your liver imaginable.
It helps the liver shed its fat very effectively, and this is partially because it helps induce lipophagy.
15
Coffee is literally known as the magic bean for liver diseases for this reason.
Drinking more coffee is incredibly protective against every liver disease you can think of.
More on that here:
Drinking more coffee is incredibly protective against every liver disease you can think of.
More on that here:
View Tweet
16
SEED OILS are REQUIRED for fatty liver disease - even with alcohol.
In fact, fatty liver disease wasn't discovered until a few decades ago, as we started eating more seed oils.
The oxidative damage of the fats in seed oils are what damages the liver and impairs fat export.
In fact, fatty liver disease wasn't discovered until a few decades ago, as we started eating more seed oils.
The oxidative damage of the fats in seed oils are what damages the liver and impairs fat export.
17
Beef tallow prevents alcoholic fatty liver disease.
Corn oil destroys the liver.
In fact, supplementing pure saturated fat can reverse liver disease in animals.
Corn oil destroys the liver.
In fact, supplementing pure saturated fat can reverse liver disease in animals.
18
Remove seed oils - fatty liver is reversed.
Reducing linoleic acid, the main fat in seed oils, to 4% of the diet literally cured every single patient of their fatty liver here.
The metabolites of linoleic acid are markers of liver disease.
Reducing linoleic acid, the main fat in seed oils, to 4% of the diet literally cured every single patient of their fatty liver here.
The metabolites of linoleic acid are markers of liver disease.
19
Seed oils cause fatty liver - vitamin E reverses it.
Vitamin E is essentially the antidote to seed oils.
In this study, we showed that a high linoleic acid (LA, the main fat in seed oils) diet induced obesity and fatty liver.
Adding in vitamin E stopped both.
Vitamin E is essentially the antidote to seed oils.
In this study, we showed that a high linoleic acid (LA, the main fat in seed oils) diet induced obesity and fatty liver.
Adding in vitamin E stopped both.
20
More on the importance + benefits and how to use vitamin E here:
View Tweet
21
Infrared light reverses fatty liver.
A major chunk of the sun's energy is dissipated as infrared radiation,
and this type of energy:
◇ Reduces inflammation
◇ Sheds liver fat
◇ Improves fat burning
Get in the sun!
A major chunk of the sun's energy is dissipated as infrared radiation,
and this type of energy:
◇ Reduces inflammation
◇ Sheds liver fat
◇ Improves fat burning
Get in the sun!
22
Red, near infrared and infrared light sources have incredible protective effects on oxidative stress and inflammation.
I've gone into that more here:
I've gone into that more here:
View Tweet
23
Taurine reverses fatty liver.
Another important antioxidant nutrient, taurine also:
◇ Improves mitochondrial function
◇ Inhibits fat synthesis
◇ Forms bile acids
all of which help heal the liver.
Here, taurine reversed fatty liver even without weight loss.
Another important antioxidant nutrient, taurine also:
◇ Improves mitochondrial function
◇ Inhibits fat synthesis
◇ Forms bile acids
all of which help heal the liver.
Here, taurine reversed fatty liver even without weight loss.
24
Taurine is one of my favorites, and I've written all about how it works and how to get enough of it here:
View Tweet
25
Low dose vitamin K2 reverses fatty liver disease.
Less than 1 mg (human equivalent dose) MK-7 daily completely protects and regenerates the liver.
K2 acts as an aid in the mitochondrial chain, improving fat metabolism in the process.
Less than 1 mg (human equivalent dose) MK-7 daily completely protects and regenerates the liver.
K2 acts as an aid in the mitochondrial chain, improving fat metabolism in the process.
26
More on vitamin K2 here:
View Tweet
27
Aspirin was recently shown to improve fatty liver, too.
Just a baby aspirin:
◇ Inhibits fat release from the fat tissue
◇ Lowers inflammation
both of which are important for protecting the liver.
More on aspirin below.
Just a baby aspirin:
◇ Inhibits fat release from the fat tissue
◇ Lowers inflammation
both of which are important for protecting the liver.
More on aspirin below.
View Tweet
28
The nutrients methionine and choline are both vital for preventing fatty liver, too.
In fact, a methionine + choline deficient diet is one of the most common ways to induce fatty liver disease experimentlaly.
More on choline below:
In fact, a methionine + choline deficient diet is one of the most common ways to induce fatty liver disease experimentlaly.
More on choline below:
View Tweet
29
Vitamin B1 improves fatty liver disease.
Injecting 50 mg (human equivalent dose) of Thiamine HCl into animals completely protected the liver from fat and damage.
Critical for systemic energy metabolism and detoxification/antioxidant status.
Injecting 50 mg (human equivalent dose) of Thiamine HCl into animals completely protected the liver from fat and damage.
Critical for systemic energy metabolism and detoxification/antioxidant status.
30
More on B1 below.
View Tweet