The neural geometrodynamics framework of psychedelics. 🧵1/10
Nicholas Fabiano, MD@NTFabiano
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Jan 13, 2025
~1 min read
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The neural geometrodynamics framework of psychedelics.
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These findings are from a study in @Entropy_MDPI which explored the intersection of neural dynamics and the effects of psychedelics in light of distinct timescales in a framework integrating concepts from dynamics, complexity, and plasticity. mdpi.com/1099-4300/26/1… 2/10
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It is termed the neural geometrodynamics framework for its parallels with general relativity’s description of the interplay of spacetime and matter. 3/10
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The geometry of trajectories within the dynamical landscape of “fast time” dynamics are shaped by the structure of a differential equation and its connectivity parameters, which evolve over “slow time” driven by state-dependent and state-independent plasticity mechanisms. 4/10
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While the adjustment of plasticity processes (metaplasticity) takes place in an “ultraslow” time scale. 5/10
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Psychedelics flatten the neural landscape, leading to heightened entropy and complexity of neural dynamics, as observed in neuroimaging and modeling studies linking increases in complexity with a disruption of functional integration. 6/10
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Pathological, rigid, or “canalized” neural dynamics result in an ultrastable confined repertoire, allowing slower plastic changes to consolidate them further. 7/10
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However, under the influence of psychedelics, the destabilizing emergence of complex dynamics leads to a more fluid and adaptable neural state in a process that is amplified by the plasticity-enhancing effects of psychedelics. 8/10
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This shift manifests as an acute systemic increase of disorder and a possibly longer-lasting increase in complexity affecting both short-term dynamics and long-term plastic processes. 9/10
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Overall, this framework offers a holistic perspective on the acute effects of psychedelics and their potential long-term impacts on neural structure and function. 10/10
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Read more about psilocybin and brain connectivity:
Nicholas Fabiano, MD@NTFabiano
Psilocybin leads to a profound shift in brain connectivity patterns.
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