Substances or methods that lower or block serotonin.🧵 (Also called...
Master Metabolism@lowmegatron
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Dec 11, 2024
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Substances or methods that lower or block serotonin.🧵
(Also called 5-hydroxytryptamine and 5-HT.)
(Also called 5-hydroxytryptamine and 5-HT.)
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Aspirin/ASA lowers serotonin.
"Aspirin treatment (1, 2, or 4 mg/kg/day) increased survival rate, and attenuated right ventricular hypertrophy and pulmonary arteriole proliferation in an MCT-induced PAH rat model. The effects of ASA may be related to the reduction of plasma 5-HT."
"Aspirin treatment (1, 2, or 4 mg/kg/day) increased survival rate, and attenuated right ventricular hypertrophy and pulmonary arteriole proliferation in an MCT-induced PAH rat model. The effects of ASA may be related to the reduction of plasma 5-HT."
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L-theanine lowers brain serotonin.
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Correcting a thiamine deficiency lowers brain serotonin.
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Glycine and taurine likely lower brain serotonin.
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Ginger is a serotonin receptor antagonist (blocker) and reduces stress (alcohol withdrawal) induced increases in serotonin.
Master Metabolism@lowmegatron
Ginger, Serotonin, and Metabolism (short version)
► Serotonin-deficient animals are resistant to obesity, insulin resistance, and nonalcoholic fatty liver disease
○ Ginger minimizes weight gain and increases energy expenditure
► Serotonin decreases thermogenesis by inhibiting the uncoupling protein UCP-1
► Uncoupling allows for calories to be “burned” at a higher rate, producing heat (thermogenesis)
► Inhibiting thermogenesis reduces energy expenditure, lowering “calories out”
○ Ginger increases thermogenesis
► Serotonin is elevated in people with type II diabetes
► Reducing gut serotonin improves blood sugar regulation
○ Ginger reduces weight, waist circumference, insulin resistance, triglycerides, and fasting blood sugar in humans
► Serotonin promotes energy absorption and storage, increasing weight and fat gain
○ Ginger decreases lipogenesis - the creation of fat cells
► The overproduction of serotonin in the small intestine is a “hallmark of human obesity”
► Gut serotonin is a driver of blood sugar problems
► The enzyme that creates gut serotonin is 40% higher in obese people
○ Ginger reduces weight gain, cold intolerance, constipation, dry skin, appetite, fatigue, mental and memory deficits in hypothyroid patients
► Serotonin decreases brain energy
► Brain serotonin causes hypothermia
○ Ginger is anti-serotonin and corrects serotonin-induced hypothermia
"Human obesity is characterized by an increased capacity to produce and release serotonin from the proximal small intestine, which is strongly linked to higher body mass, and glycemic control."
► Serotonin-deficient animals are resistant to obesity, insulin resistance, and nonalcoholic fatty liver disease
○ Ginger minimizes weight gain and increases energy expenditure
► Serotonin decreases thermogenesis by inhibiting the uncoupling protein UCP-1
► Uncoupling allows for calories to be “burned” at a higher rate, producing heat (thermogenesis)
► Inhibiting thermogenesis reduces energy expenditure, lowering “calories out”
○ Ginger increases thermogenesis
► Serotonin is elevated in people with type II diabetes
► Reducing gut serotonin improves blood sugar regulation
○ Ginger reduces weight, waist circumference, insulin resistance, triglycerides, and fasting blood sugar in humans
► Serotonin promotes energy absorption and storage, increasing weight and fat gain
○ Ginger decreases lipogenesis - the creation of fat cells
► The overproduction of serotonin in the small intestine is a “hallmark of human obesity”
► Gut serotonin is a driver of blood sugar problems
► The enzyme that creates gut serotonin is 40% higher in obese people
○ Ginger reduces weight gain, cold intolerance, constipation, dry skin, appetite, fatigue, mental and memory deficits in hypothyroid patients
► Serotonin decreases brain energy
► Brain serotonin causes hypothermia
○ Ginger is anti-serotonin and corrects serotonin-induced hypothermia
"Human obesity is characterized by an increased capacity to produce and release serotonin from the proximal small intestine, which is strongly linked to higher body mass, and glycemic control."
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Parathyroid hormone may (in vitro study) cause the release of serotonin and histamine from mast cells.
Common causes of high parathyroid hormone:
Calcium insufficiency
Magnesium deficiency
Vitamin D deficiency
Excessive phosphate intake
Low calcium-to-phosphate ratio
Common causes of high parathyroid hormone:
Calcium insufficiency
Magnesium deficiency
Vitamin D deficiency
Excessive phosphate intake
Low calcium-to-phosphate ratio
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Hypothyroidism increases brain serotonin (5-HT).
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Hypothyroidism is implicated in depression, a condition of low brain energy.
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The anti-histamine cyproheptadine is also a serotonin antagonist (blocker). It has been trialed with success in serotonergic conditions like IBS, cancer (in combination), schizophrenia (comb), liver cancer (comb), autism (comb), and depression (suppressible dexamethasone tests).
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Cyproheptadine is used for the emergency treatment of serotonin syndrome, a potentially fatal, often drug-induced condition caused by excessive serotonin levels in the body.
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Positive ions increase blood serotonin (5-HT).
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"Negative ions in the air seem to help the lungs to destroy the serotonin in an oxidative process." Ray Peat
This can partly explain the beneficial effects of waterfalls and the ocean on “mental” health.
This can partly explain the beneficial effects of waterfalls and the ocean on “mental” health.
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Vitamin E can lower brain serotonin.
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The anti-nausea drug Ondansetron is a serotonin blocker which is useful in IBS-D.
“Ondansetron relieves some of the most intrusive symptoms of IBS-D, namely loose stools, frequency and urgency.”
“Ondansetron relieves some of the most intrusive symptoms of IBS-D, namely loose stools, frequency and urgency.”
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Famotodine (Pepcid) as a possible treatment for serotonin syndrome - hypertension, tachycardia, retching, nausea, agitation, and semicoma mentality with no pupillary light reflex...
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Magnesium deficiency elevates brain serotonin. Increasing magnesium decreases likelihood of seizures.
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DHEA might lower serotonin by reducing the serotonin producing enzyme TPH (tryptophan hydroxylase), which is elevated by stress.
! High doses of DHEA, greater than 5 mg, especially orally, can be estrogenic !
! High doses of DHEA, greater than 5 mg, especially orally, can be estrogenic !
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Serotonin, BCAAs, athletic performance, tryptophan, and cancer.
From Serotonin, depression, and aggression: The problem of brain energy [Ray Peat]
From Serotonin, depression, and aggression: The problem of brain energy [Ray Peat]
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[6]-Gingerol is a compound in ginger.
It can reduce gut and brain serotonin by lowering the relevant enzymes (TPH1 and 2).
It also increases MAO-A which breaks down serotonin.
“[6]-gingerol significantly reduced the noted increases in TPH-1 and TPH-2 levels.”
It can reduce gut and brain serotonin by lowering the relevant enzymes (TPH1 and 2).
It also increases MAO-A which breaks down serotonin.
“[6]-gingerol significantly reduced the noted increases in TPH-1 and TPH-2 levels.”
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Linoleic acid, which is abundant in seed oils, makes platelets release serotonin into the blood.
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cy@cyclos17
In "Enriching Heredity", Marian C. Diamond talked about how "exposure of rats to high levels of negative ions increased the weight of the outer layers of the brain" and how "enriched rats living in a negative ion atmosphere had significantly less serotonin" than the placebo.
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> DHEA lowers stress-induced serotonin synthesis in the brain
> Probably highly dose-dependent
> It works on the TPH enzyme
> Probably highly dose-dependent
> It works on the TPH enzyme