Substances or methods that lower or block serotonin.🧵 (Also called...

Substances or methods that lower or block serotonin.🧵
(Also called 5-hydroxytryptamine and 5-HT.)

Aspirin/ASA lowers serotonin.
"Aspirin treatment (1, 2, or 4 mg/kg/day) increased survival rate, and attenuated right ventricular hypertrophy and pulmonary arteriole proliferation in an MCT-induced PAH rat model. The effects of ASA may be related to the reduction of plasma 5-HT."

L-theanine lowers brain serotonin.

Correcting a thiamine deficiency lowers brain serotonin.

Glycine and taurine likely lower brain serotonin.

Ginger is a serotonin receptor antagonist (blocker) and reduces stress (alcohol withdrawal) induced increases in serotonin.
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Parathyroid hormone may (in vitro study) cause the release of serotonin and histamine from mast cells.
Common causes of high parathyroid hormone:
Calcium insufficiency
Magnesium deficiency
Vitamin D deficiency
Excessive phosphate intake
Low calcium-to-phosphate ratio

Hypothyroidism increases brain serotonin (5-HT).

Hypothyroidism is implicated in depression, a condition of low brain energy.

The anti-histamine cyproheptadine is also a serotonin antagonist (blocker). It has been trialed with success in serotonergic conditions like IBS, cancer (in combination), schizophrenia (comb), liver cancer (comb), autism (comb), and depression (suppressible dexamethasone tests).

Cyproheptadine is used for the emergency treatment of serotonin syndrome, a potentially fatal, often drug-induced condition caused by excessive serotonin levels in the body.

Positive ions increase blood serotonin (5-HT).

"Negative ions in the air seem to help the lungs to destroy the serotonin in an oxidative process." Ray Peat

This can partly explain the beneficial effects of waterfalls and the ocean on “mental” health.