I've been on daily Cialis (tadalafil) for over a year now, but not...
Michael Morelli@morellifit
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Sep 14, 2026
~3 min read
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I've been on daily Cialis (tadalafil) for over a year now, but not for sex.
It's actually a highly effective tool for overall blood flow, cardiovascular health and potentially hair health.
I'd even say it's a longevity drug.
Tadalafil, explained: (1/16)
It's actually a highly effective tool for overall blood flow, cardiovascular health and potentially hair health.
I'd even say it's a longevity drug.
Tadalafil, explained: (1/16)
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Tadalafil is the generic name, while Cialis is the brand. It belongs to the same drug class as Viagra, known as PDE5 inhibitors, but it behaves differently.
The main difference is the half-life: tadalafil stays active for about 17.5 hours, compared to only 4 hours for Viagra.
The main difference is the half-life: tadalafil stays active for about 17.5 hours, compared to only 4 hours for Viagra.
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Because of that long half-life, you do not have to time it around specific moments.
A low daily dose keeps a consistent level in your system, keeping blood vessels relaxed around the clock without needing to plan ahead.
A low daily dose keeps a consistent level in your system, keeping blood vessels relaxed around the clock without needing to plan ahead.
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It was designed this way on purpose and received FDA approval in 2003.
In some places, it earned the nickname "the weekend pill" because a single dose can remain active for up to 36 hours, providing a steady baseline over a couple of days.
In some places, it earned the nickname "the weekend pill" because a single dose can remain active for up to 36 hours, providing a steady baseline over a couple of days.
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How does tadalafil work?
The body widens blood vessels using nitric oxide, which increases a molecule called cGMP to relax vessel walls.
An enzyme called PDE5 normally breaks cGMP down, but tadalafil blocks that enzyme from doing so.
The body widens blood vessels using nitric oxide, which increases a molecule called cGMP to relax vessel walls.
An enzyme called PDE5 normally breaks cGMP down, but tadalafil blocks that enzyme from doing so.
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This means the drug does not force blood flow, but simply removes the restriction on your body's natural system.
It allows vessels to stay open longer wherever PDE5 is present, including in lung and prostate tissue.
It allows vessels to stay open longer wherever PDE5 is present, including in lung and prostate tissue.
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The most well-known effect is supporting erections.
Higher cGMP levels mean better blood flow during natural arousal.
It is not an aphrodisiac and does not create desire; it simply addresses the physical mechanics of blood flow.
Higher cGMP levels mean better blood flow during natural arousal.
It is not an aphrodisiac and does not create desire; it simply addresses the physical mechanics of blood flow.
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A lesser-known area of interest is hair health.
Improved scalp circulation might support hair follicles if poor blood flow is contributing to thinning.
While it is not a proven standalone hair treatment, it shares a mechanism with tools like minoxidil.
Improved scalp circulation might support hair follicles if poor blood flow is contributing to thinning.
While it is not a proven standalone hair treatment, it shares a mechanism with tools like minoxidil.
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The impact on cardiovascular health is also frequently discussed.
Research has shown that men with high cardiovascular risk factors saw improvements in endothelial function, which is the health of the blood vessel lining itself, when using the compound.
Research has shown that men with high cardiovascular risk factors saw improvements in endothelial function, which is the health of the blood vessel lining itself, when using the compound.
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It appears to go beyond just maintaining cGMP levels.
Some data suggests it helps the vessel lining produce more nitric oxide independently.
In studies of men with type 2 diabetes, regular use correlated with improved artery function and fewer markers of vessel damage.
Some data suggests it helps the vessel lining produce more nitric oxide independently.
In studies of men with type 2 diabetes, regular use correlated with improved artery function and fewer markers of vessel damage.
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Large cohort studies tracking over a million men have also noted an association between regular PDE5 inhibitor use and lower rates of cardiovascular events.
While this is an association rather than direct proof, the correlation is notable.
While this is an association rather than direct proof, the correlation is notable.
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Gym goers often use it to improve their training response.
Better blood flow means increased vascularity and potentially better nutrient delivery to working muscles.
It does not directly build muscle or add weight to your lifts though.
Better blood flow means increased vascularity and potentially better nutrient delivery to working muscles.
It does not directly build muscle or add weight to your lifts though.
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In terms of how it is typically used, FDA-approved daily dosing sits at 2.5 to 5 milligrams for steady, consistent levels.
As-needed dosing of 10 to 20 milligrams is also approved.
As-needed dosing of 10 to 20 milligrams is also approved.
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I’ve been on 5 mg of daily tadalafil for over a year now.
I recently decided to increase the dose to 5 mg in the morning and 5 mg in the evening.
I can safely report noticeable benefits for my cardiovascular health, my blood pressure, and my performance in bed.
I recently decided to increase the dose to 5 mg in the morning and 5 mg in the evening.
I can safely report noticeable benefits for my cardiovascular health, my blood pressure, and my performance in bed.
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Also, never mix tadalafil with nitrates such as nitroglycerin or certain recreational variants.
The combination can cause a dangerous drop in blood pressure. Guidelines require waiting at least 48 hours after your last dose before nitrates can be given.
The combination can cause a dangerous drop in blood pressure. Guidelines require waiting at least 48 hours after your last dose before nitrates can be given.
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Quick note: nothing in this thread is medical advice. Tadalafil is a prescription drug, so talk to your doctor before using it.
What works for one person may not be right for you, and self-medicating without guidance carries real risks.
What works for one person may not be right for you, and self-medicating without guidance carries real risks.
