Can Nattokinase Reverse Atherosclerosis? 🫀❤️🔥 (link in 6/6) 1/6)...
Nick Norwitz MD PhD@nicknorwitz
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Jan 14, 2026
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Can Nattokinase Reverse Atherosclerosis? 🫀❤️🔥
(link in 6/6)
1/6) When it comes to cardiovascular health, few supplements have sparked as much public interest — or confusion — as #nattokinase.
This enzyme, derived from Japanese fermented soybeans, has achieved near-legendary status for its potential to improve, or even reverse, atherosclerosis.
But the hype surrounding nattokinase is often matched by a lack of understanding — both about how it works and whether it actually works.
(link in 6/6)
1/6) When it comes to cardiovascular health, few supplements have sparked as much public interest — or confusion — as #nattokinase.
This enzyme, derived from Japanese fermented soybeans, has achieved near-legendary status for its potential to improve, or even reverse, atherosclerosis.
But the hype surrounding nattokinase is often matched by a lack of understanding — both about how it works and whether it actually works.
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2/6) Let’s start with some human data.
In one study, 29,000 participants were followed for 16 years.
People in the highest quartile of nattō consumption, compared with those in the lowest quartile, had a 25% lower risk of dying from cardiovascular disease (HR = 0.75), after adjusting for covariates.
In one study, 29,000 participants were followed for 16 years.
People in the highest quartile of nattō consumption, compared with those in the lowest quartile, had a 25% lower risk of dying from cardiovascular disease (HR = 0.75), after adjusting for covariates.
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3/6) Because this is an observational study, you should reasonably worry about “healthy‑user bias.”
But what’s especially interesting is that the researchers found no significant associations between cardiovascular mortality and total soy protein intake or other soy foods — the signal was specific to natto.
Let that fact ferment for a second.
But what’s especially interesting is that the researchers found no significant associations between cardiovascular mortality and total soy protein intake or other soy foods — the signal was specific to natto.
Let that fact ferment for a second.
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4/6) Enter nattokinase — an enzyme made during the fermentation process.
In another experiment involving 1,062 participants, researchers administered 10,800 FU/d over a year.
They observed: a measurable regression of atherosclerosis (21.7% reduction in CIMT)
In another experiment involving 1,062 participants, researchers administered 10,800 FU/d over a year.
They observed: a measurable regression of atherosclerosis (21.7% reduction in CIMT)
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5/6) How nattokinase works is fascinating!
It has at least three broad effects:
👉Anti-thrombotic (anti-blood clotting)
👉Anti-hypertensive (blood pressure)
👉Antioxidant.
(I'll break it all down in the letter, link in 6/6)
*And, yes, that’s a Nick Norwitz original. I did not steal it from the Louvre.
It has at least three broad effects:
👉Anti-thrombotic (anti-blood clotting)
👉Anti-hypertensive (blood pressure)
👉Antioxidant.
(I'll break it all down in the letter, link in 6/6)
*And, yes, that’s a Nick Norwitz original. I did not steal it from the Louvre.
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6/6) In Today’s full letter, we break it all down, including more human data, RCTs, mechanisms and dosing.
This is Nat-to be missed: staycuriousmetabolism.substack.com/p/nattokinase-…
This is Nat-to be missed: staycuriousmetabolism.substack.com/p/nattokinase-…
