Aging causes what I call 'chronic jet lag syndrome' It's a perma...
Siim Land@siimland
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Aug 11, 2025
~2 min read
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Aging causes what I call 'chronic jet lag syndrome'
It's a perma debuff that reduces the amplitude in circadian hormones, sleep duration, deep sleep and recovery.
Ultimately, you start aging much more rapidly after this happens
Here's a thread to postpone this⬇️⬇️
youtu.be/YICImvaTRZ4
It's a perma debuff that reduces the amplitude in circadian hormones, sleep duration, deep sleep and recovery.
Ultimately, you start aging much more rapidly after this happens
Here's a thread to postpone this⬇️⬇️
youtu.be/YICImvaTRZ4
2
With age, the body's circadian rhythms go through many changes:
- dampening of circadian hormones like melatonin and cortisol (less fluctuations)
- reduced circadian signaling through the eyes and brain
- shorter sleep and more fragmented sleep
= NOT GOOD
PMID: 28145903
- dampening of circadian hormones like melatonin and cortisol (less fluctuations)
- reduced circadian signaling through the eyes and brain
- shorter sleep and more fragmented sleep
= NOT GOOD
PMID: 28145903
3
As a result, older people sleep less than younger ones
Not that they need less sleep but because their bodies become less capable to do so because of damage to the circadian system with age
PMID: 15586779
Not that they need less sleep but because their bodies become less capable to do so because of damage to the circadian system with age
PMID: 15586779
4
Melatonin levels decrease with age and older people produce significantly less melatonin
That shortens their sleep but melatonin is also a massive antioxidant and anti-aging hormone Lower melatonin = less repair and faster aging
PMID: 17408483
That shortens their sleep but melatonin is also a massive antioxidant and anti-aging hormone Lower melatonin = less repair and faster aging
PMID: 17408483
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Melatonin is the hormone of darkness and one of the main circadian hormones
The decline in melatonin due to aging is primarily caused by damage to the circadian system
Thus, one of the best longevity strategies is to maintain high melatonin production
The decline in melatonin due to aging is primarily caused by damage to the circadian system
Thus, one of the best longevity strategies is to maintain high melatonin production
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Fortunately, it's been found that it's possible to reverse this 'chronic jet lag syndrome' and damage to the circadian system
The key metabolite for that is NAD+ which is an enzyme with many longevity benefits but one of its main effects is circadian regulation
PMID: 28880862
The key metabolite for that is NAD+ which is an enzyme with many longevity benefits but one of its main effects is circadian regulation
PMID: 28880862
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There are some ways to raise NAD levels:
- calorie restriction
- exercise
- fasting
- lowering inflammation
- inhibiting CD38
- circadian rhythm alignment
Check out my full thread about NAD:
- calorie restriction
- exercise
- fasting
- lowering inflammation
- inhibiting CD38
- circadian rhythm alignment
Check out my full thread about NAD:
Siim Land@siimland
NAD is considered a longevity molecule
It decreases with age and low levels of NAD accelerate the hallmarks of aging
But most people go about raising NAD levels the wrong way
Here's a thread about how to maximize your natural NAD production and minimize its loss⬇️⬇️
It decreases with age and low levels of NAD accelerate the hallmarks of aging
But most people go about raising NAD levels the wrong way
Here's a thread about how to maximize your natural NAD production and minimize its loss⬇️⬇️
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The 'chronic jet lag syndrome' coincides with the decrease in NAD as NAD is involved with the circadian rhythms
Circadian rhythm alignment is also linked to NAD production and recycling
Thus, it's a vicious cycle: circadian disruption causing low NAD and vice versa
Circadian rhythm alignment is also linked to NAD production and recycling
Thus, it's a vicious cycle: circadian disruption causing low NAD and vice versa
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To sum it up:
- circadian rhythms get disoriented with age, which accelerates aging through lowering NAD, and melatonin and reducing sleep quality
- it's possible to reverse this deterioration through NAD metabolism
- NAD requires circadian alignment
- circadian rhythms get disoriented with age, which accelerates aging through lowering NAD, and melatonin and reducing sleep quality
- it's possible to reverse this deterioration through NAD metabolism
- NAD requires circadian alignment
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