READ THIS IF YOU ARE ALWAYS TIRED (no matter how much you rest)....

The quintessential metabolism maximizing nutrient.

From crushing fatigue, improving digestion and even cancer support -

VITAMIN B1 might just be what you need:

The reason you can’t lose weight (or keep it off) no matter how hard you try.

LEPTIN: why it’s SO important and how to optimize yours to boost your metabolism and finally stay thin for life.

LACTIC ACID - a sign things are going wrong.

· Anxiety / panic attacks
· Fatigue, especially in muscle
· Shortness of breath

Are all signs of high lactic acid.

It is produced in large amounts when metabolism is impaired (Warburg Effect). This is famous for happening in cancer.

Excess lactic acid also drives:

· Insulin resistance
· Inflammation
· Stress (sympathetic nervous system + HPA axis)

Some things that can lower lactic acid:

· Thyroid hormone
· Methylene blue
· B1, B2, B3, B6, B7
· Anything to lower stress

You can measure it in the blood. It's not all encompassing but it's a good marker.

x.com/Outdoctrinatio…

CANDIDA: The cause of your terrible gut health and fatigue that your doctor has no idea how to fix.

Here’s how to know if you have it, what causes it and what to do about it:

READ THIS IF YOU WANT TO FIX YOUR GUT.

If you have IBS, bloating, gas, poor bowel movements or brain fog, you NEED to see this.

This is a comprehensive DEEP dive into fixing your digestive health:

High cortisol, anxiety, and can’t sleep? This is for you.

This is the ULTIMATE GUIDE to STRESS - the signs, the biological mechanisms and what to do about it:

The key to unlocking your metabolism, mood, energy and gut health is sitting under your tongue being ignored by your doctor.

This is the ULTIMATE AND COMPLETE GUIDE TO THYROID HEALTH so you can optimize it:

Keto, Carnivore and Fasting are DECIMATING your metabolism.

The thyroid needs carbs.

Here’s why:

CARBON DIOXIDE:

Not a waste product or a villain in global warming, but an enhancer for your metabolism.

THREAD:

How a cheap clothing dye can turbocharge your energy production, bolster your mood and cognition, and prevent disease in the long run

Let’s talk about METHYLENE BLUE. How it works

[THREAD]

An incredibly powerful tool for mental & cognitive health.

It heals depression, brain damage, Alzheimer's, and keeps your mind sharp.

The benefits of RED / INFRARED LIGHT THERAPY for the brain are astonishing:

If I were trying to prevent / mitigate the effects of a major oxidative insult (serious drug exposure, radiation, heavy metals, major trauma, etc.):

☆ Vitamin E
☆ Vitamin C
☆ B1
☆ B2
☆ Selenium
☆ Copper
☆ Zinc
☆ NAc
☆ Glycine
☆ Taurine
☆ Red / near infrared / sun light
☆ Foods rich in these nutrients (liver, oysters, meat, gelatinous foods)
☆ Foods rich in flavonoids (fruits, whole juices, coffee, chocolate)
☆ Edible mushrooms (ergothioneine)
☆ Plenty of carbohydrates
☆ Avoid polyunsaturated fat (seed oils) like the plague
☆ Run iron labs, potentially some more comprehensive panels if serious enough

NAC + glycine is an anti-aging, metabolic elixir.

➜ Reduces oxidative stress
➜ Improves mitochondrial function
➜ Improves cognitive function
➜ Reverses insulin resistance

Nearly every metric of aging and disease imaginable.

More on glycine below: x.com/Outdoctrinatio…

If you feel puffy, have “cortisol face,” are congested and feel like your body needs a reset, look no further.

You’re probably filled up with fluid that won’t leave until you address this.

Let’s talk about the LYMPH STAGNATION - why it is harmful & how to fix it:

The effects of BRIGHT LIGHT on your mood are more important than anyone realizes.

If you’re feeling down, tired, stressed, or anxious, this may just be the answer you never knew you needed.

I found that out the hard way.

Here’s why:

PREGNENOLONE: A fountain of youth

1. Pregnenolone lowers stress - restores youthful appearance

As we age, we:

☞ Put on more fat
☞ Lose muscle
☞ Produce less energy
☞ Do so in a more stressful manner

The primary stress hormone, cortisol, actually predicts your perceived age.

In other words, the lower your stress, the younger you appear to other people, and the younger you likely are biologically!

Stress directly promotes the breakdown of

☞ Skin
☞ Hair
☞ Muscle

while promoting the creation of fat mass.

Pregnenolone INHIBITS the release of CRH, the hypothalamic precursor of cortisol.

Prengnolone’s ability to inhibit the release of CRH/CRF is unique, targeting stress at the most basic biological root cause.

Pregnenolone also functionally inhibits the receptor for cortisol.

The "pregnenolone facelift" phenomenon is real.

The production of pregnenolone and its metabolites like DHEA, declines in aging, while the production of stress steroids like cortisol continue to rise.

The ratio of DHEA/Cortisol is one of the best predictors of disease and mortality, and declines with aging.

Pregnenolone also gets metabolized in large quantities to progesterone, which also inhibits CRH release and is a direct antagonist on the cortisol receptors.

Progesterone has GABAnergic effects, which is the key relaxing signaling molecule in the body.

Another compound which pregnenolone largely gets converted into is allopregnanolone, our body’s primary endogenous GABAnergic steroid.

2. Pregnenolone is anti-inflammatory

CRH, independently of cortisol production, also contributes to stress, disease and aging, by initiating inflammation.

Inflammation is uniformly seen in all chronic diseases and in the aging process, as it

☞ Breaks down our tissue
☞ Dampens energy production
☞ Generally makes us feel crappy

Pregnenolone actually degrades the toll like receptors (TLRs) that initiate inflammation in conditions from Alzheimer's disease to IBS.

3. Pregnenolone increases energy

As we age, our mitochondria become:

☞ More susceptible to damage
☞ More fragmented
☞ Smaller
☞ Less effective at producing energy,
☞ More prone to generate free radicals

but pregnenolone allows them to

☞ Produce more energy,
☞ Produce less with oxidative stress
☞ Undergo fusion, when mitochondria come together and become more robust.

The pro-energy effects of pregnenolone have been observed for nearly a century.

Some early studies showed that workers, especially those under stress, subjectively felt better when doing so with pregnenolone.

This anti-fatigue effect was also demonstrated in arthritic patients.

100-500 mg of pregnenolone taken orally has consistently shown an anti-fatigue, cognitive enhancing and anti-stress/anxiety effect.

I'll link the pregnenolone we use ourselves and with clients below.

Perhaps the most noteworthy testimonial:

" 'I didn't have my usual summer recovery from "winter sickness,' during a two week trip I felt perfectly well, but except for that short time I kept getting sicker and sicker (with inflammation of arteries, dental abscesses, asthma, migraines, and colitis).

Lying in bed one day trying to understand what had happened during that two week trip, I remembered that I had used the vitamin E containing a residue of pregnenolone on the trip, but used pure vitamin E after I got home.

I immediately got out of bed and took a pinch of pregnenolone. In about an hour, all of my
symptoms had stopped, and for over a week I was healthy and energetic.

But then I got sick again, and was so distracted by the pain that it was several days before I remembered the pregnenolone. Another pinch had the same dramatic sudden effect.

Since then I have taken some almost every day."

- Ray Peat

Look at his transformation!

The miracle medicine that’s sitting in your kitchen, and costs you almost nothing.

It sheds fat, improves insulin resistance, stops kidney stones, and might even turn cancer cells back to normal.

The benefits of VINEGAR will absolutely blow your mind:

CAFFEINE is so much more than a stimulant.

It's actually one of the most powerful anti-aging, anti-inflammatory and neuroprotective tools known to man, yet it's been demonized.

The TRUTH about caffeine will blow your mind:

Modern medicine’s greatest contribution to the health of mankind.

It heals cancer, depression and is even a nootropic.

And it’s safe and cheap to boot.

Why ASPIRIN is so much more than a painkiller and a blood thinner:

The animal-based, anti-aging nutrient you aren't getting enough of.

It protects the brain, reduces inflammation, stress, insulin resistance, and might even grow your hair.

The benefits of TAURINE are boundless:

HEAVY METALS - the complete guide on how you get exposed, sick, and what to do about it:

SOURCES OF HEAVY METAL EXPOSURE:

The main heavy metals of concern are aluminum, nickel, cadmium, lead, arsenic, and mercury.

Due to pollution and industrialization, these elements that normally reside deep in the earth have been introduced to our environment in unprecedented amounts.

As a result, heavy metals have made their way into damn near every aspect of our modern lives.

● Vegetables - due to soil contamination
● Grains (especially brown rice)
● Canned foods - using metals
● Chocolate (especially dark)
● Pesticides - which incorporate heavy metals
● Seafood (especially larger fish) - as the ocean gets contaminated from pollution
● Vaccines - used as preservatives
● Water
● Medical devices
● Cigarettes / vapes
● The air itself
● Supplements
● Dental devices
● Utensils
● Aluminum foil
● Cookware (+ utensils)
● Drugs
● Jewelry
● Tattoos
● Glassware
● Cars (especially working on engines)
● Batteries
● Wires
● Paint (especially old)
● Piping
● Sewage
● Ceramic
● Gasoline / oil
● Grills/charcoal
● Personal care products
● Cosmetics
● Baking powder
● Food additives

If you work in a lab, with batteries, cars, if you’re a welder, electrician, or any type of manual labor that requires contact with metal, oil, gas, or other industrial processes, chances are you’re getting disproportionately exposed to these.
HEAVY METAL TOXICITY SIGNS / SYMPTOMS:

These poisons have such a fundamental way of disrupting normal biology / biochemistry that they can impact nearly every aspect of health.

◍ Mental / cognitive health
◍ Fat gain
◍ Hormonal disruptions
◍ Liver problems
◍ Cancer
◍ Gut issues - IBS, IBDs
◍ Respiratory issues
◍ Fatigue
◍ Kidney problems
◍ Heart diseases
MECHANISMS OF HEAVY METAL TOXICITY.

While metals can be toxic, our body NEEDS certain metals, or minerals.

Zinc, copper, iron, magnesium, manganese, etc. etc.

These are essential elements that are intertwined, literally, with every fiber of our being.

Toxic heavy metals use this property, essentially “hacking” the role of many of these nutrients, due to their chemical similarity.

As a result, they:

◍ Bind to native proteins and enzymes
◍ Deplete antioxidants
◍ Cause oxidative stress
◍ Drive inflammation
◍ Increase intracellular calcium
◍ Impair mitochondrial function

However, while this property creates their toxicity, it also leads to the most logical way to deal with them - by “outnourishing” them.

Many of our essential minerals have built in ways of protecting us from heavy metals.

◍ Iron deficiency increases lead and cadmium absorption
◍ Iron also mitigates arsenic toxicity
◍ Calcium deficiency increases lead absorption and impairs excretion.
◍ Zinc stimulates the production of metallothionein, which binds heavy metals
◍ Selenium protects against mercury toxicity
MOLYBDENUM is a little known nutrient that literally prevents death from mercury poisoning.

Research has shown that giving molybdenum alongside mercury completely prevented death from an otherwise completely lethal mercury treatment.

Molybdenum also helps increase the excretion of heavy metals.

Molybdenum has shown protection against lead poisoning, too.

Lead can be incredibly dangerous by replacing iron and inhibiting red blood cell formation, which we need to breathe and survive.

Molybdenum prevents that.

Molybdenum is most abundant in liver, as well as grains and beans, plus cottage cheese.

Supplementing during heavy metal toxicity can have benefits.

Selenium markedly improves mercury toxicity & increases its excretion.

Mercury interacts with selenium dependent proteins, causing oxidative damage.

Supplementing selenium binds to mercury and supports its elimination, while preventing oxidative stress.

Selenium is in brazil nuts, beef, organ meats and more.
One study showed that a zinc & selenium combination mitigate heavy metal toxicity.

A mixture of various toxic heavy metals was combatted by supplementing zinc+selenium:

• Restores antioxidant enzymes
• Lowers inflammation
• Prevents cell death, tissue damage
• Lowers absorption of heavy metals

A study in battery workers found that zinc + vitamin C powerfully reduces heavy metals in the body.

‣ Both prevent absorption of lead, cadmium, etc
‣ Zinc directly promotes their excretion by producing metallothionein
‣ Both critical for antioxidant protection against them

Trace minerals are some of our best protection.

Aluminum is known to induce Alzheimer's plaques, but Vitamin E reverses it.

Aluminum is higher in neurodegenerative conditions in the brain - causing oxidative damage and cognitive decline.

Vitamin E is one of our primary protectors.
Another paper demonstrated that vitamin E + selenium mitigate mercury poisoning.

Due to their therapeutic effect on oxidative stress, they are able to prolong survival during mercury exposure.

Magnesium also improves lead toxicity & enhances its excretion.

Lead likes to accumulate in the bones and become a slow poison over time, but ample magnesium can mitigate this.

Magnesium supplementation is a no brainer for most, especially during heavy metal overload.

Silicon is a mineral that lowers aluminum in tissues.

➢ Brain
➢ Liver
➢ Bone
➢ Spleen
➢ Kidney

all have drastically reduced aluminum content when enough of this mineral are included in the diet.

Prevents aluminum absorption and improves excretion.

Thiamine (vitamin B1) can lower lead stores in the body.

B1 binds lead and prevents it from being locked up in tissues where it can cause toxicity.

Something important to remember is that heavy metals get excreted in large part through the feces.

That means if your gut is slow or not functioning well, you're going to have a tough time getting it all out - sorting out gut health is going to be VITAL.

Some things that aid in the binding and excretion of heavy metals through the gut:

✦ Fiber: insoluble fibers like wheat bran
✦ Pectin: especially modified citrus pectin
✦ Humic / fulvic acid (found in shilajit)
✦ Bentonite clay
✦ Charcoal
✦ Taurine / glycine (for bile)

You'll also want to support your detoxification systems in general.

The body has a myriad of ways to inactivate and excrete various toxins.

There are also a number of natural compounds that can bind and aid in the excretion of heavy metals.

◈ Glutathione (made from glycine)
◈ N-Acetylcysteine
◈ Taurine
◈Allium sativum (garlic)
◈ Milk thistle
◈ Cilantro
◈ Ginkgo
◈ Turmeric
◈ Triphala
◈ Phytochelatins

There are also chemical chelators of heavy metals.

◈ DMSA
◈ ALA
◈ EDTA

and others.

I would exert EXTREME CAUTION if trying to go this route, since these can take metals and redistribute them into different tissues.

Done properly, it can be helpful, but doing it properly is very difficult.

TESTING FOR HEAVY METALS:

Blood testing is considered the gold standard, and is more reflective of recent exposure.

Urine is more representative of excretion and long term exposure.

Hair testing is relatively unreliable since it can easily be externally contaminated.

Nail testing is more promising, but not very well studied.

I would opt for blood + urine in most cases, if suspecting heavy metal toxicity.

This is how you know for sure. I would not undergo any of these interventions without a strong suspicion of heavy metal toxicity.

I spent over $1,000 on lab testing to optimize my health.

I wanted to dive deep into my metabolism to see what I could discover.

So deep, you probably haven’t even heard of most of these metrics.

Here’s everything I learned:

READ THIS IF YOU ARE ALWAYS TIRED (no matter how much you rest).

It's not in your head. It's not normal, but it is fixable.

Let's talk about what causes FATIGUE + TIREDNESS, and what you can do about it to have flying energy levels for life: