READ THIS IF YOU ARE ALWAYS TIRED (no matter how much you rest).
It's not in your head. It's not normal, but it is fixable.
Let's talk about what causes FATIGUE + TIREDNESS, and what you can do about it to have flying energy levels for life:
Mitochondria are the engines of your cells, and thus your body.
They take food and oxygen, and convert it into usable energy.
If they aren't working optimally, your “battery” never charges.
Focusing on them is thus the key to solving low energy, so that is what we will do:
They take food and oxygen, and convert it into usable energy.
If they aren't working optimally, your “battery” never charges.
Focusing on them is thus the key to solving low energy, so that is what we will do:
Vitamins & minerals are needed for your cells to create energy from food.
⬩B1
⬩B2
⬩B3
⬩B6
⬩Magnesium
⬩Zinc
⬩Copper
⬩Iron
⬩Sulfur
⬩CoQ10
⬩K2
⬩Creatine
Just to name a few.
If you're low on any, you're already screwed.
⬩B1
⬩B2
⬩B3
⬩B6
⬩Magnesium
⬩Zinc
⬩Copper
⬩Iron
⬩Sulfur
⬩CoQ10
⬩K2
⬩Creatine
Just to name a few.
If you're low on any, you're already screwed.
Vitamin B1 megadosing can cure fatigue.
600 - 1,500 mg of thiamine (B1) reduced fatigue severity by ~40%
Multiple studies showing this.
Perhaps the most important nutrient for the mitochondria.
More on that below.
600 - 1,500 mg of thiamine (B1) reduced fatigue severity by ~40%
Multiple studies showing this.
Perhaps the most important nutrient for the mitochondria.
More on that below.
View Tweet
Coenzyme Q10 has potent energizing properties.
60 mg per day prevented and even improved fatigue in patients with heart failure.
CoQ10 is a central compound in mitochondria: a lack of it impairs our ability to generate energy
i.e you get tired.
60 mg per day prevented and even improved fatigue in patients with heart failure.
CoQ10 is a central compound in mitochondria: a lack of it impairs our ability to generate energy
i.e you get tired.
Magnesium cuts fatigue in half.
People with persistent fatigue have depleted magnesium stores,
but 6 weeks of magnesium, subjective energy level improves by >50%.
Magnesium is necessary to form cellular energy in the form of ATP, and supports multiple energy producing enzymes.
People with persistent fatigue have depleted magnesium stores,
but 6 weeks of magnesium, subjective energy level improves by >50%.
Magnesium is necessary to form cellular energy in the form of ATP, and supports multiple energy producing enzymes.
Mitochondria don’t just run on vitamins and minerals though, you need to EAT ENOUGH CALORIES,
Restricting calories also body drops thyroid hormone and leptin to conserve energy.
You’re not just eating less, you’re telling your body to produce less energy.
More on that below.
Restricting calories also body drops thyroid hormone and leptin to conserve energy.
You’re not just eating less, you’re telling your body to produce less energy.
More on that below.
View Tweet
When mitochondria can’t generate ATP properly, your cells fall back on glycolysis - a less efficient form of energy production.
This leads to excess lactic acid buildup, especially after activity. This is a hallmark of chronic fatigue.
This leads to excess lactic acid buildup, especially after activity. This is a hallmark of chronic fatigue.
View Tweet
And it’s not just in your muscles.
Studies show people with chronic fatigue have elevated lactate in the brain’s cerebrospinal fluid.
Again, this is a sign of impaired energy generation in the brain.
Studies show people with chronic fatigue have elevated lactate in the brain’s cerebrospinal fluid.
Again, this is a sign of impaired energy generation in the brain.
NAD+ is a coenzyme that carries electrons for energy production.
Low NAD+/NADH ratio = stalled mitochondrial output and higher lactic acid production.
Higher ratio = more ability to burn energy.
The ratio drops when energy production is off, and further shuts down the system.
Low NAD+/NADH ratio = stalled mitochondrial output and higher lactic acid production.
Higher ratio = more ability to burn energy.
The ratio drops when energy production is off, and further shuts down the system.
Nicotinamide Mononucleotide (NMN) reduces fatigue.
Raising NAD+ with precursors (NMN, NR, niacinamide) restores energy production in mitochondria, since it is often limited by NAD+ availability.
250mg here was shown to have an energizing effect.
Raising NAD+ with precursors (NMN, NR, niacinamide) restores energy production in mitochondria, since it is often limited by NAD+ availability.
250mg here was shown to have an energizing effect.
ENDOTOXIN (LPS) is a primary driver of impaired energy generation.
This is a part of most gut bacteria, and circulate systemically if your gut health is poor.
Endotoxin inhibits mitochondrial energy production at multiple levels.
This is a very common cause of fatigue.
This is a part of most gut bacteria, and circulate systemically if your gut health is poor.
Endotoxin inhibits mitochondrial energy production at multiple levels.
This is a very common cause of fatigue.
Eating meals higher in fat can increase the absorption of endotoxin into the blood.
This is especially problematic if you already have bacterial overgrowth / dysbiosis and leaky gut.
Lower fat / higher fiber can help mitigate, but ultimately you need to fix the gut.
This is especially problematic if you already have bacterial overgrowth / dysbiosis and leaky gut.
Lower fat / higher fiber can help mitigate, but ultimately you need to fix the gut.
Fatigue doesn’t come far behind once digestion becomes burdened.
Consistently and strongly associated with elevated levels of intestinal permeability, gut bacterial toxicity and subsequent inflammation.
Consistently and strongly associated with elevated levels of intestinal permeability, gut bacterial toxicity and subsequent inflammation.
Chronic fatigue often starts in the gut.
An overproduction of D-Lactic acid bacteria are prominent in chronic fatigue, contributing to brain fog and tiredness.
Antibiotics can reverse it.
An overproduction of D-Lactic acid bacteria are prominent in chronic fatigue, contributing to brain fog and tiredness.
Antibiotics can reverse it.
Chronic fatigue caused by candida.
These fungi can:
◇ Drive chronic inflammation
◇ Suppress the immune system, increasing pathogenic load
Contributing to fatigue pathology.
Anti-fungal interventions can resolve Chronic Fatigue Syndrome.
More on tackling it below.
These fungi can:
◇ Drive chronic inflammation
◇ Suppress the immune system, increasing pathogenic load
Contributing to fatigue pathology.
Anti-fungal interventions can resolve Chronic Fatigue Syndrome.
More on tackling it below.
View Tweet
That means you MUST focus on the gut if you want to overcome chronic fatigue.
Lucky for you, I have a guide on how to do just that below:
Lucky for you, I have a guide on how to do just that below:
View Tweet
Inflammation is one of the primary mitochondrial inhibitors.
⇒ Inhibits mitochondrial enzymes
⇒ Fragments them into inefficient pieces
⇒ Triggers oxidative stress (damages structure + stop energy uptake)
This is why you get tired when you get sick, but you can have chronic inflammation that makes you chronically tired.
⇒ Inhibits mitochondrial enzymes
⇒ Fragments them into inefficient pieces
⇒ Triggers oxidative stress (damages structure + stop energy uptake)
This is why you get tired when you get sick, but you can have chronic inflammation that makes you chronically tired.
Chronic fatigue is really chronic inflammation.
Microglia (inflammatory cells, red/yellow) in the brain are directly tied to symptoms of:
△ Cognitive impairment
△ Depression
△ Pain
△ Lethargy
interventions that address inflammation will be key in solving it.
Microglia (inflammatory cells, red/yellow) in the brain are directly tied to symptoms of:
△ Cognitive impairment
△ Depression
△ Pain
△ Lethargy
interventions that address inflammation will be key in solving it.
Viruses are a primary trigger of fatigue.
Some researchers think that MOST cases of chronic fatigue are initiated by a virus.
Common ones:
⇨ EBV reduces mitochondrial DNA replication.
⇨ HHV-6B and CMV increase oxidative stress
All viruses can ramp up inflammation and derail your cellular energy systems.
Some researchers think that MOST cases of chronic fatigue are initiated by a virus.
Common ones:
⇨ EBV reduces mitochondrial DNA replication.
⇨ HHV-6B and CMV increase oxidative stress
All viruses can ramp up inflammation and derail your cellular energy systems.
Generated by Thread Navigator
Press ⌘ + S to quick-export
auto_awesome
Image exported!
Pro export renders embedded tweets & media at 2x Retina resolution.
Upgrade — $5 for 30 days