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🚨GUT MASTERCLASS🚨

7 KEYS to fixing your digestive issues:

1. BACTERIA

Probably the most important thing to address.

Issues with gut bacteria (dysbiosis) will directly worsen everything else on this list.

Dysbiosis will drive:

⬩Pain
⬩Gas
⬩Sensitization
⬩Bloating
⬩Poor motility
⬩Food intolerances
⬩Inflammation
⬩Diarrhea
⬩Poorly formed stools
⬩Constipation

2 key easy and free ways to tell if you have dysbiosis:

1. Coated / white tongue in the morning (especially in the back)
2. Consistent foamy urine

Both very common signs of bacterial issues.

Stool testing is nice if you're really stuck, but if these are prevalent along with other gut symptoms - you can bet dysbiosis is an issue.

3 primary levers to pull to fix dysbiosis:

⬩Diet
⬩Antimicrobials
⬩Probiotics

For Diet: Starting with a low residue diet that limits bacterial fermentation.

Animal protein/fat: all cuts of beef, lamb, bison, etc. + eggs, seafood, dairy as tolerated (cottage cheese and Greek yogurt the least offensive typically)

+ easily digestible carbs like fruit juices, cane sugar and honey.

A low FODMAP diet can be effective if the problem is more upper GI (belching, upper bloating, lack of appetite).

& NO MATTER WHAT: keep polyunsaturated fats LOW (seed oils mainly).

+ Avoid food additives: added iron, colors, gums, dyes, etc. It's all terrible.

From there, in general, the least problematic foods to add back in order seem to be:

⬩Whole fruit
⬩Very well cooked potatoes / rice
⬩Toasted / non whole / cooked grains (sourdough)
⬩Very well cooked green vegetables

The better you get, the more you ought to expand the diet to make the gut more robust over time. You don't want to have a restrictive diet long term.

In general - over or under-eating will make things worse. Listen to your body.

For antimicrobials: low dose, safe antibiotics can be an absolute life saver.

⬩100-200 mg penicillin, 3-4x a day for 1-3 weeks
⬩25 mg doxy/minocycline, 2x a day, for 1-3 days

have been the most reliable in my experience.

Some natural antimicrobials:

⬩Oregano oil
⬩Allicin (garlic/onion)
⬩Mastic gum
⬩Pau D'Arco
⬩Rosemary
⬩Thyme
⬩Activated charcoal
⬩Wormwood
⬩Camphor
⬩Carrot
⬩Berberine

One herbal protocol that was studied: 2 capsules each of proprietary blends (you can get these online) FC Cidal + Dysbiocide or Candibactin-AR + Candibactin-BR, 2x a day for 4 weeks

PROBIOTICS: I wouldn't start with these if the problem is really bad, but I think the closer you get back to normal, the more important they become.

Probiotics:

⬩Have antimicrobial/anti-biofilm effects
⬩Essential for gut immunity
⬩Enhance gut motility
⬩Can metabolize food components

In general - multi strain, long duration is the key to success. At least 2 months is a good starting point.

I like the Ruscio triple therapy, MegaSporeBiotic and Seed products.

2. GUT MOTILITY

Absolutely vital to keep things moving. If you don't:

⬩Greater bacterial fermentation
⬩More inflammation from food lingering
⬩More gas production, retention (bloating)

Some tools to enhance gut motility:

⬩Coffee
⬩Cascara
⬩Triphala
⬩Raw carrot

Walking consistently is also essential here, as is maintaining consistent sleep / wake times, since gut motility is coordinated by the circadian rhythm.

The most important aspect of gut motility is vagal tone - the primary governor of the "rest and digest" nervous system that allows things to flow along well.

Which brings me to...

3. STRESS

Stress will destroy digestion. It:

⬩Worsens gut immunity - allowing for dysbiosis
⬩Slows motility (but can also cause diarrhea)
⬩Impairs energy production

Obviously, solving stress is a massive puzzle, but supporting the vagal cholinergic system here is paramount for the gut.

⬩B1
⬩Choline(rgics)

Are vital nutrients.

⬩Pregnenolone
⬩Progesterone
⬩Humming
⬩Acupressure points
⬩Breathing practices
⬩Sunlight
⬩Maintaining circadian rhythm
⬩Grounding

Are all important levers to pull for increasing vagal tone.

Deficiencies of pretty much any nutrient can cause stress, but the most noteworthy anti-stress nutrients IMO are:

⬩Magnesium
⬩Vitamin D
⬩Carbohydrate
⬩Salt
⬩Potassium
⬩Vitamin C

4. ENERGY

If your metabolism sucks good luck digesting anything.

You need energy for:

⬩Stomach acid
⬩Digestive enzyme secretion
⬩Motility
⬩Immunity
⬩Maintaining "good" bacterial balance

Some keys to enhancing energy production:

⬩Thyroid optimization / supplementation
⬩B vitamins
⬩Copper
⬩Limiting polyunsaturated fats

Eat ya liver and oysters.

5. SEROTONIN

Something NOBODY talks about but is VITAL to target.

You WILL have excess gut serotonin if you have these issues. It directly drives:

⬩Nausea
⬩Pain
⬩Sensitivity
⬩Diarrhea
⬩Bloating
⬩Loss of appetite

and more.

Serotonin is primarily the result of dysbiosis and gut irritation, so the bacteria / diet notes apply here as well.

Some tools that can directly lower serotonin and give immediate relief:

⬩Ginger
⬩Lysine
⬩Vitamins A & D
⬩Zinc

and some drugs:

⬩Cyproheptadine
⬩Benadryl
⬩Zofran (Ondansetron)
⬩Famotidine

This is so so important I will link my post on it below.

6. INFLAMMATION + LEAKY GUT

Inflammation is what directly facilitates a lot of these symptoms.

The breakdown of the intestinal barrier, or "leaky gut," is a common underlying theme in all digestive problems that drives inflammation.

Everything mentioned above plays a key role in driving or managing inflammation and the intestinal barrier,

but some good foods to directly target it:

⬩Gelatinous meats / bone broth (glycine + hydroxyproline)
⬩Raw milk
⬩Orange juice

Good supplements that directly lower inflammation:

⬩Lactoferrin
⬩Zinc Carnosine
⬩BPC-157
⬩Glutamine

The best thing you can do for your health that no one is talking about.

You’ll be sleeping like a baby, reducing your stress, and crushing inflammation.

Literally touch grass.

Why GROUNDING is the missing link to your optimal health:

PREGNENOLONE: A fountain of youth

1. Pregnenolone lowers stress - restores youthful appearance

As we age, we:

☞ Put on more fat
☞ Lose muscle
☞ Produce less energy
☞ Do so in a more stressful manner

The primary stress hormone, cortisol, actually predicts your perceived age.

In other words, the lower your stress, the younger you appear to other people, and the younger you likely are biologically!

Stress directly promotes the breakdown of

☞ Skin
☞ Hair
☞ Muscle

while promoting the creation of fat mass.

Pregnenolone INHIBITS the release of CRH, the hypothalamic precursor of cortisol.

Prengnolone’s ability to inhibit the release of CRH/CRF is unique, targeting stress at the most basic biological root cause.

Pregnenolone also functionally inhibits the receptor for cortisol.

The "pregnenolone facelift" phenomenon is real.

The production of pregnenolone and its metabolites like DHEA, declines in aging, while the production of stress steroids like cortisol continue to rise.

The ratio of DHEA/Cortisol is one of the best predictors of disease and mortality, and declines with aging.

Pregnenolone also gets metabolized in large quantities to progesterone, which also inhibits CRH release and is a direct antagonist on the cortisol receptors.

Progesterone has GABAnergic effects, which is the key relaxing signaling molecule in the body.

Another compound which pregnenolone largely gets converted into is allopregnanolone, our body’s primary endogenous GABAnergic steroid.

2. Pregnenolone is anti-inflammatory

CRH, independently of cortisol production, also contributes to stress, disease and aging, by initiating inflammation.

Inflammation is uniformly seen in all chronic diseases and in the aging process, as it

☞ Breaks down our tissue
☞ Dampens energy production
☞ Generally makes us feel crappy

Pregnenolone actually degrades the toll like receptors (TLRs) that initiate inflammation in conditions from Alzheimer's disease to IBS.

3. Pregnenolone increases energy

As we age, our mitochondria become:

☞ More susceptible to damage
☞ More fragmented
☞ Smaller
☞ Less effective at producing energy,
☞ More prone to generate free radicals

but pregnenolone allows them to

☞ Produce more energy,
☞ Produce less with oxidative stress
☞ Undergo fusion, when mitochondria come together and become more robust.

The pro-energy effects of pregnenolone have been observed for nearly a century.

Some early studies showed that workers, especially those under stress, subjectively felt better when doing so with pregnenolone.

This anti-fatigue effect was also demonstrated in arthritic patients.

100-500 mg of pregnenolone taken orally has consistently shown an anti-fatigue, cognitive enhancing and anti-stress/anxiety effect.

I'll link the pregnenolone we use ourselves and with clients below.

Perhaps the most noteworthy testimonial:

" 'I didn't have my usual summer recovery from "winter sickness,' during a two week trip I felt perfectly well, but except for that short time I kept getting sicker and sicker (with inflammation of arteries, dental abscesses, asthma, migraines, and colitis).

Lying in bed one day trying to understand what had happened during that two week trip, I remembered that I had used the vitamin E containing a residue of pregnenolone on the trip, but used pure vitamin E after I got home.

I immediately got out of bed and took a pinch of pregnenolone. In about an hour, all of my
symptoms had stopped, and for over a week I was healthy and energetic.

But then I got sick again, and was so distracted by the pain that it was several days before I remembered the pregnenolone. Another pinch had the same dramatic sudden effect.

Since then I have taken some almost every day."

- Ray Peat

Look at his transformation!

When Vitamin C stopped cancer.

Patients with terminal cancer given ~10 g vitamin C per day.

◉ Vit. C increased survival time by 3X for most of them
◉ Increased survival time by at least 20X for about 10%
◉ 53X as many people made it over a year

compared with controls.

LACTOFERRIN: A “miracle” supplement for your gut.

1. Lactoferrin is a powerful gut anti-inflammatory

Lactoferrin was known to prevent and even cure cancer in the digestive tract of animals.

A research group decided to apply this in humans.

Patients given 3 grams of lactoferrin had their colon tumors slow in growth significantly.

A 22 year old young man with severe Crohn’s disease caught wind of these results.

He just moved to the United States and had lost access to the hefty medications he was on.

He decided to try 1 gram of lactoferrin daily for himself.

Cured.

Lactoferrin at just 100 mg/day helped in Crohn’s disease, decreasing levels of the inflammatory markers IL-6 and hepcidin.

One trial showed that 3 grams of lactoferrin per day resulted in 50% fewer incidences of diarrhea in just 2 weeks.

2. Any digestive symptom - lactoferrin can help

Lower doses of lactoferrin are still a godsend for severe digestive symptoms.

Another study showed lactoferrin at 600 mg daily diminished nausea, diarrhea and abdominal pain.

One report of children who consumed lactoferrin at 100 mg / day showed a reduction in vomiting and gut inflammation.

3. Lactoferrin is antibacterial, antifungal and regulates iron

Lactoferrin is critically important for its regulation of IRON.

While iron is of course essential, it is a double edged sword.

Unabsorbed free iron, which we are exposed to so much in today's food and in disease, directly causes inflammation and bacterial overgrowth in the gut.

Lactoferrin is critical for chelating and ENHANCING intestinal absorption of iron.

Lactoferrin acts as an iron transporter and thus REDUCES oxidative damage in the gut's nervous system.

Think of iron literally rusting on your most vital tissues: lactoferrin is there to PREVENT this.

It also boosts the expression of the famous BDNF in the gut, which allows the gut’s nervous system to regenerate properly.

These gut based nerves are responsible for perceiving digestive symptoms, as well as numerous regulating motility which is impaired in digestive distress.

But the ultimate root cause of these digestive conditions is typically bacterial.

Lactoferrin has potent antibacterial effects, in part by binding with free iron.

This deprives more pathogenic bacteria of this essential growth element,

while actually providing iron to some commensal bacteria which have lower iron requirements.

Lactoferrin also has direct antimicrobial properties by disrupting bacterial cell membranes.

It also increases the activity of serine protease, and antimicrobial peptides like RegIII𝛾, enzymes which shred up bacteria.

Lactoferrin has even been found to be effective against a variety of Candida species, an infamous fungus that causes gut and systemic infections in humans.

4. Lactoferrin heals the structure of the gut

Lactoferrin is essential for both the creation and the differentiation of the intestinal epithelial into all of the cellular subtypes necessary to keep the gut functioning properly.

Disruptions in the gut epithelial barrier can lead to antigens entering the area just underneath these cells,

triggering the release of a variety of cytokines and contributing to intestinal inflammation.

This is a phenomenon seen in EVERY digestive disease, and many other conditions seemingly unrelated to the gut.

If you suffer from bloating, gut pain, loose stools or poor bowel habits, or issues like poor sleep, mood and skin problems, you can bet that this process is involved.

HOWEVER, lactoferrin contributes to MAINTAINING the intestinal epithelial barrier and has immunomodulatory properties,

which are both critical functions in protecting the gut mucosal immune system.

Lactoferrin has been shown to support intestinal barrier integrity by upregulating tight junction protein expression and protecting the intestine from bacterial infections.

I cannot stress enough how important this is.

This is the most prevalent mechanism in any digestive condition you can think of, and lactoferrin can help prevent and heal it!

5. Lactoferrin calms the immune system

Lactoferrin could be a viable solution to addressing lactose intolerance.

It promotes the production of key digestive enzymes that break down lactose and sugar.

If you seem to react poorly to a myriad of normal foods (skin reactions, loose stools, diarrhea, brain fog, etc), then lactoferrin could be the solution.

We have various immune cells that are constantly sampling components of the gut to recognize the normal while weeding out pathogens.

But this process can become impaired and our immune systems can become overactive, mounting unwarranted inflammatory responses,

& driving tons of different digestive symptoms and intolerances to otherwise normal foods.

However, lactoferrin influences immune cells to become more tolerant, and less inflammatory, preventing various gut symptoms.

Essentially, it helps your immune system properly differentiate between what should and shouldn’t require inflammation.

Secretory IgA is an immune component that serves a PIVOTAL role in gut health.

It binds to pathogenic bacteria and other antigens from the environment and prevents them from causing inflammation.

sIgA is known to get depleted during times of stress, and its absence tends to result in inflammatory problems in the gut.

However, lactoferrin supplementation has been shown to INCREASE sIgA production in the gut,

supporting our immunity and protecting us from bacterial overgrowths and infections that can wreak havoc on our gut health.

Toll-like receptors (TLRs) are another critical mediator of intestinal inflammation, sensing various bacterial components in the gut like endotoxin.

These receptors are elevated in the gut of people with IBS and inflammatory bowel diseases,

yet lactoferrin has been shown to REDUCE their expression, leading to subsequent quelling of inflammation.

6. What is lactoferrin?

Lactoferrin is a protein that is found mainly in MILK, at its highest concentrations in colostrum, the milk the mother produces when lactation first begins.

This milk needs to be incredibly enriched in regenerative components for the offspring to survive and develop at this most crucial period.

Bovine colostrum has been consumed for millennia for its God-like medicinal properties.

Even Cleopatra was said to use it as it was seen as an immortal ingredient.

7. How to use it

Therapeutic doses range from 100 mg up to 3 grams of lactoferrin daily.

Makes sense to start at the lower end and gradually increase, though it is very safe so trying higher doses can be an option.

Of course you can also get it from bovine milk (20-200 mg/L) or colostrum (2g/L), especially when raw,

but the amount is variable and it can be tough to consume enough to hit the therapeutic targets.

Human milk is even higher in lactoferrin, if you're really adventurous.

I'll link the supplement we use with clients below, it's been such a key to our success!