Circadian clock dysfunction affects virtually all the hallmarks of...
Siim Land@siimland
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Sep 12, 2025
~1 min read
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1
Circadian clock dysfunction affects virtually all the hallmarks of aging:
- chronic inflammation
- mitochondrial dysfunction
- loss of autophagy
- gut dysbiosis
- cell senescence
- telomere shortening
Graph: PMID: 36583849
- chronic inflammation
- mitochondrial dysfunction
- loss of autophagy
- gut dysbiosis
- cell senescence
- telomere shortening
Graph: PMID: 36583849
2
With aging, circadian clocks lose robustness:
- Reduced amplitude of rhythms (weaker hormone and gene oscillations)
- Phase advance (earlier sleep/wake times)
- Impaired synchronization (due to weaker light sensitivity, sedentary lifestyle, irregular habits)
Graph: PMID: 36583849
- Reduced amplitude of rhythms (weaker hormone and gene oscillations)
- Phase advance (earlier sleep/wake times)
- Impaired synchronization (due to weaker light sensitivity, sedentary lifestyle, irregular habits)
Graph: PMID: 36583849
3
I just had a podcast with @GregPotterPhD who is a circadian rhythm expert
We break down how circadian clock dysfunction contributes to aging and how you can maintain better circadian clock function with age
youtu.be/eu4IP8VO80Y
We break down how circadian clock dysfunction contributes to aging and how you can maintain better circadian clock function with age
youtu.be/eu4IP8VO80Y