I used to have DEBILITATING allergies every year. Couldn't even go...

- Histamine
- Serotonin
- Prostaglandins
- Leukotrienes
- Type 2 cytokines (IL-3, IL-4, IL-5, IL-9 IL-13)
These drive excess mucus production, itch, airway thickening / constriction, redness… everything.
The primary cells involved in releasing them are:
- Mast cells
- Eosinophils
- Basophils
- Neutrophils
- T Cells
This system is in place to protect us against things like parasites and foreign toxins. It helps us eliminate them effectively before they cause even more damage.
The question is, what causes the increased production of these chemicals from these cells unnecessarily?
Why do some people’s immune cells release more of these mediators in response to things that are harmless like pollen?
In fact, around 80% of your immune cells reside in the gut, and they are major players in your susceptibility to allergies.
Poor gut health can wreck your immune system's ability to properly deal with allergens in a few ways:
◈ Bad bacteria shift the balance of T cells away from an anti-inflammatory (regulatory) state to a pro-inflammatory one (Th2/Th17)
◈ Intestinal permeability exposes the immune system to more allergens by allowing "leakage"
◈ Inflammation / bacteria can stimulate innate lymphoid cells (ILC2 via IL-25, IL-33, TSLP), which activates eosinophils, mast cells and B cells to produce IgE
◈ The gut is the biggest source of histamine + serotonin in the entire body by far.
The two threads below get more into that last point.

This is A KEY culprit wreaking havoc on your gut that your doctor won’t even think about.
Here’s how it’s tearing up your insides (and what to do about it):
Animals given butyrate were protected from allergies, as they had:
⬩Less anaphylaxis
⬩Lower IgE
⬩More “tolerant” / anti-inflammatory immune cells
⬩Reduced mast cell degranulation - the release of histamine
Butyrate also:
⬩Seals up leaky gut
⬩Promotes T cells to differentiate into the regulatory type
Your gut produces lots of butyrate when it's healthy, and lacks it when it doesn't
You can also supplement it for tons of benefits, which I wrote about below.

It is a godsend for IBS, Crohn’s, Ulcerative Colitis and even colon cancer.
Why BUTYRATE might be your key optimal digestion + gut health:
My masterclass on doing just that is here:

If you have IBS, bloating, gas, poor bowel movements or brain fog, you NEED to see this.
This is a comprehensive DEEP dive into fixing your digestive health:
Vitamins A+D are probably the most important.
The metabolites of each act on the genetic level in immune cells.
Both, in unison, increase the gene expression of proteins involved in immune tolerance, away from excessive activation.
Vitamin A - beef liver, egg yolks, dairy fat
Vitamin D - seafood, the sun
50,000 IU weekly of vitamin D reduces:
◇ Itchiness
◇ Runny nose
◇ Sneezing
◇ Postnasal drip
◇ Eye swelling
with trends for reducing other symptoms too.

WAY beyond preventing colds, it enhances brain function, crushes stress and massively improves energy.
Let's talk about the multifaceted benefits of VITAMIN D:
Vitamin A is so important for the immune system as it is needed for the multiplication of immune cells,
as well as their transformation into their proper types.
Here, it reduced lung damage, as well as markers like IgE in asthma.

It heals the gut, grows the brain, can boost testosterone and gives us glowing skin.
These are the miraculous benefits of VITAMIN A, plus how to make sure you get enough.
THREAD:
Vitamin C is one of our primary buffers of oxidative stress (free radicals).
Excessive oxidative stress, especially in neutrophils, can directly drive the inflammatory response in mast cells and in T cells, the main mediators of allergies.
Vitamin C also supports collagen synthesis, which reduces allergen exposure, and has some epigenetic mechanisms of supporting the immune response.
In kiwis, peppers, citrus fruit / juices, berries, veggies.
7.5g as an IV.
➜ 90% of patients improved symptoms
➜ On average symptoms improved by 80%
➜ Massive reductions in itchiness + nasal inflammation
Prevents histamine release from mast cells by lowering oxidative stress.

⇨ Anti-cancer
⇨ Lowers stress
⇨ Renews skin
⇨ Improves sex life
⇨ Enhances energy & motivation
⇨ Crushes anxiety
⇨ Reduces sickness
& more.
Let's talk about the benefits of it, how to get enough and supplementation.
THREAD:
⇨ Reduces allergen exposure (improves barrier function)
⇨ Mitigates oxidative stress (drives mast cell degranulation / cytokine production)
⇨ Shifts T cells away from Th2 towards tolerance
Zinc also is needed for vitamin A metabolism.
Oysters, beef, cheese.

That's just scratching the surface.
The benefits of ZINC are nearly endless:
Glucocorticoids released from the adrenal glands shift T-cells towards the Th2 type - the type that contributes to allergies.
CRH, released from the hypothalamus in the cortisol production cascade, directly promotes the number and activation of mast cells.
Lowering cortisol / stress is going to be paramount in overcoming allergies.
I put together a masterclass on doing just that below.

This is the ULTIMATE GUIDE to STRESS - the signs, the biological mechanisms and what to do about it:
Pregnenolone + progesterone also have their own independent anti-inflammatory effects,
which also help shift T cells towards their non allergenic state.

Pregnenolone: what it is, how it works, and why adding it in as a supplement could be a game changer for you.
[THREAD]
Administering nicotine:
◇ Reduces mast cell proliferation
◇ Inhibits inflammatory T-Cell responses
◇ Allergic symptoms
The nicotinic acetylcholine receptors of the immune system have anti-inflammatory effects.
Acetylcholine is the primary "rest and digest" relaxing neurotransmitter.
Key nutrients for acetylcholine:
• Choline
• B1
• B2
• B5
• B9
• B12
• Glycine
• Creatine
Improving parasympathetic (cholinergic) tone:
• Grounding
• Humming
• Breathing practices
• Pregnenolone
• Progesterone

It's anti-aging, anti-inflammatory, cognitive enhancing and even aids in fat loss.
The benefits of NICOTINE will shock you:
1/2 tsp stops the inflammatory response by activating the vagus nerve,
which connects to the spleen and calms down inflammation of the resident white blood cells.
A few reports have recorded a halt in life threatening allergic responses with baking soda.

It combats fatigue, inflammation, stress and even cancer.
You won’t believe the incredible health benefits of BAKING SODA:
Some of the biggest inherited risks of developing allergies are genetic impairments in mitochondrial function.
These energy producers in our cells are at the epicenter of so many cellular events it's hard to keep track of.
Dendritic cells, which can present allergens to other immune cells, are highly tolerant when they have high energy production capacity.
They don't alarm the rest of the immune system unnecessarily if their energy production is satisfied.
If mitochondria aren't working properly, they have multiple ways of contributing to allergies throughout the immune system:
◇ Increase calcium content in cells - which drives inflammatory responses (especially mast cell degranulation)
◇ Drive oxidative stress - which does the same
◇ Creates immunogenic (not tolerant) immune cells
I went into greater detail on optimizing mitochondrial function in the thread below.

It's not in your head. It's not normal, but it is fixable.
Let's talk about what causes FATIGUE + TIREDNESS, and what you can do about it to have flying energy levels for life:
◇ Sneezing
◇ Stuffy nose
◇ Runny nose
◇ Itchiness
◇ Watery eyes
◇ Swelling eyes
ALL reduced.
Vitamin E is the one of the body's primary antioxidants,
and also inhibits the production of leukotrienes, which are released from mast calls.

For the poisons of the modern world, VITAMIN E is one of the best tools to maintain your health.
Here's why:
➥ Leukotrienes
➥ Prostaglandins (prostanoids)
are two of the primary chemicals released by mast cells and eosinophils to produce allergic symptoms.
They are both metabolites of the omega 6 linoleic acid, the fat most abundant in seed oils.
A high omega 6 / omega 3 ratio predisposes to allergies.
Raw honey improves allergies.
3-5 tsp day improved sniffles, sneezing, & more
Has tons of antioxidant compounds that:
‣ Inhibit mast cell histamine release
‣ Blunt inappropriate IgE responses
‣ Lowers production of inflammatory cytokines

You won't believe the incredible benefits of RAW HONEY:
☆ B1
☆ B2
☆ Selenium
☆ Zinc
☆ NAc
☆ Taurine
☆ Foods rich in flavonoids (fruits, whole juices, coffee, vegetables, chocolate)
☆ Edible mushrooms (ergothioneine)
☆ Plenty of carbohydrates
☆ Avoiding excess iron
Feeding raw milk reduced:
• Inflammatory cell migration, cytokine production
• Respiratory symptoms
while heated milk did not.
Proteins like lactoferrin and immunoglobulins, with immune regulatory properties, are degraded with heat.

It is a godsend for digestion, prevents allergies, lowers inflammation and even improves cognition.
Why RAW MILK is a superfood:
Other tools to lower / oppose estrogen:
‣ Saturated fat
‣ Aspirin
‣ Vitamin B2
‣ White button mushrooms
‣ Insoluble fiber (raw carrot)
‣ Naringin, naringenin, apigenin (citrus fruits)

Just some of the things that the incredible PROGESTERONE can do (even for guys).
Here’s how:
‣ L-Carnosine
‣ Diamine oxidase
‣ L. Plantarum
‣ Ginger
‣ Skullcap
‣ Quercetin
‣ Curcumin
‣ Lidocaine
If you want some help in optimizing your health, we've got you covered. Schedule a call here with us prism.miami/scheduling

Couldn't even go outside without breaking out into tears and itches.
Now I forget that they even exist.
This is what I learned about allergies, the science of how they work, and what you can do to break free of them:
pubmed.ncbi.nlm.nih.gov/18165213/pubmed.ncbi.nlm.nih.gov/6522095/ parasites
nature.com/articles/natur… toxins
sciencedirect.com/science/articl… rev natural compounds
nature.com/articles/s4139… rev mechs
pmc.ncbi.nlm.nih.gov/articles/PMC90… mito rev
pmc.ncbi.nlm.nih.gov/articles/PMC11… neut rev
link.springer.com/article/10.100… T cells + stress
pmc.ncbi.nlm.nih.gov/articles/PMC10… gut rev
link.springer.com/referenceworke… ROS rev (drives inflammation from DAMPS, HNE/dna damage drives NFKB)
pmc.ncbi.nlm.nih.gov/articles/PMC38… FMT contagious
nature.com/articles/s4157… bad gut bugs activate ILC2
pmc.ncbi.nlm.nih.gov/articles/PMC11…pmc.ncbi.nlm.nih.gov/articles/PMC59… vit A/D
pmc.ncbi.nlm.nih.gov/articles/PMC11… zinc
pmc.ncbi.nlm.nih.gov/articles/PMC99… C
Vit E / Seed oils pubmed.ncbi.nlm.nih.gov/15237767/sciencedirect.com/science/articl…





















































