@Outdoctrination: SEROTONIN (the "happy hormone"...
@Outdoctrination
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May 13, 2024
1
SEROTONIN (the "happy hormone") is the PRIMARY cause of digestive problems.
Here's how (and what to do it about it):
Bloating, gas, pain, diarrhea, constipation, general discomfort, sensitivity, histamine problems can ALL be directly caused by serotonin.
Like serotonin acts on neurons in your brain, it acts on neurons in your GUT to create these unpleasant sensations and movement disorders.
A powerful serotonin blocking drug, cyproheptadine, has been shown in several studies to cure all of these problems. No exaggeration.
Back when I had debilitating gut problems, cyproheptadine was the first and only thing that actually worked, that made my gut feel normal again.
Ondansetron (Zofran) is a highly efficacious anti-nausea drug, which also blocks serotonin.
Meanwhile, to induce IBS in an animal, give them the genetic equivalent of an SSRI.
SSRIs also double the risk of developing IBS.
Genetic variants that increase serotonin in the gut also raise IBS risk.
Serotonin is elevated in the gut of every GI disease.
IBS, IBDs, you name it.
Excess bacteria, whether considered good or bad, can stimulate serotonin production in the gut.
One way that has been extremely useful for me in diagnosing this is looking at the tongue.
The tongue should be a vibrant pink, almost red, in good health. Saliva production should be strong.
When bacterial issues arise, the tongue gets a white coating, especially in the back.
The mouth to the anus is really one long track, and thus bacterial issues in the intestines and associated dysmotility (digestive contractions up instead of down) can cause the coated tongue.
Antigens on bacteria trigger inflammatory cascades, resulting in increased serotonin.
Constipation, leading to bacterial buildup, is a huge issue here. The mere presence of stool in the gut is sufficient to cause serotonin production.
This can become a vicious cycle, as bacteria use serotonin to enhance their virulence through biofilm formation.
Natural laxatives like coffee are helpful for alleviating constipation, as well as ensuring adequate magnesium intake (I prefer glycinate as a supplement).
Keeping consistent sleep/wake/eat times for the circadian rhythm is huge too, the entire gut depends on this.
Digestive enzymes, motility, stomach acid, and antimicrobial peptides coordinate based on the time of day.
So making sure your body knows what time it is is key.
Motility is slowed and fecal load is high in all types of gut problems, even diarrhea.
Serotonin can bind to mast (immune) cells, which release histamine.
It’s been hypothesized that histamine intolerance actually starts in the gut.
This goes both ways, as antihistamines also tend to lower serotonin, and diamine oxidase supplementation (from pork kidney) can also help with gut problems.
Benadryl and famotidine (Pepcid) are two popular OTC choices that can have rapid digestive benefits in part by lowering serotonin.
Any type of fiber can promote serotonin production.
Soluble fiber feeds bacteria, and insoluble fiber acts as an irritating agent.
Food additives can increase gut serotonin.
The short chain fatty acids produced by the microbial fermentation also drive serotonin production.
Low or no fiber diets can CURE many of these problems.
IBS, IBD and diverticulitis patients consistently improve massively from no fiber diets.
Not that you need to avoid fiber for life, but if your gut is highly compromised, it's probably the last thing you want more of.
In severe cases, pharmaceutical antibiotics may be helpful.
You are playing with fire, don't get me wrong, but smart implementation of antibiotics can have some incredible effects.
Personally, I had immense benefit from very low dose tetracyclines and penicillin.
Natural antibacterials can also be beneficial. Some good ones:
‣ Oregano oil
‣ Allicin (garlic/onion)
‣ Mastic gum
‣ Pau D'Arco
‣ Rosemary
‣ Thyme
‣ Wormwood
‣ Camphor
‣ Carrot
‣ Berberine
The antibacterial blends Dysbiocide + FC Cidal or Candibactin-AR + Candibactin-BR have been shown to be equivalent to antibiotics for bacterial issues.
Vitamin A/D/zinc inhibit the key enzyme responsible for serotonin synthesis (TPH1).
All of the fat soluble vitamins also have direct antimicrobial properties.
K2 is a huge one for me.
Of course, all stems from poor metabolism and stress.
Bacterial issues can especially arise when gut metabolism is suboptimal. In this case, oxygen is not used for energy, and instead leaks into the gut.
Higher oxygen environments foster the growth of more and more pathogenic gut bacteria, and this is seen in every GI disease.
So the primary mitochondrial nutrients, B1/2/3/5/6/7, copper, iron, sulfur, electrolytes and thyroid hormone, are also critical to master.
A lack of allopregnanolone (a metabolite of pregnenolone/progesterone) and/or DHT, is known to induce gut problems via serotonin increase.
Allopregnanolone reverses this effect, and administering pregnenolone / progesterone can work wonders as well.
Of course, there are also antiserotonin drugs.
Cyproheptadine played an absolutely huge role in my recovery from debilitating gut problems.
Some other antiserotonin agents are L-Lysine, methysergide, metergoline, LSD, ketanserin, and ondansetron. [NOT MEDICAL ADVICE]
The serotonin transporter relies on sodium to pull serotonin into cells and deactivate it, and low salt diets increase serotonin.
Lower salt diets also impair insulin sensitivity and can raise cortisol.
The cortisol precursor, CRH, also increases gut inflammation and serotonin. Stress kills.
Pregnenolone / progesterone are our endogenous anti-CRH steroids.
Fasting also increases serotonin levels in the gut and systemically.
Doesn't that all sound so happy?
Here's how (and what to do it about it):
Bloating, gas, pain, diarrhea, constipation, general discomfort, sensitivity, histamine problems can ALL be directly caused by serotonin.
Like serotonin acts on neurons in your brain, it acts on neurons in your GUT to create these unpleasant sensations and movement disorders.
A powerful serotonin blocking drug, cyproheptadine, has been shown in several studies to cure all of these problems. No exaggeration.
Back when I had debilitating gut problems, cyproheptadine was the first and only thing that actually worked, that made my gut feel normal again.
Ondansetron (Zofran) is a highly efficacious anti-nausea drug, which also blocks serotonin.
Meanwhile, to induce IBS in an animal, give them the genetic equivalent of an SSRI.
SSRIs also double the risk of developing IBS.
Genetic variants that increase serotonin in the gut also raise IBS risk.
Serotonin is elevated in the gut of every GI disease.
IBS, IBDs, you name it.
Excess bacteria, whether considered good or bad, can stimulate serotonin production in the gut.
One way that has been extremely useful for me in diagnosing this is looking at the tongue.
The tongue should be a vibrant pink, almost red, in good health. Saliva production should be strong.
When bacterial issues arise, the tongue gets a white coating, especially in the back.
The mouth to the anus is really one long track, and thus bacterial issues in the intestines and associated dysmotility (digestive contractions up instead of down) can cause the coated tongue.
Antigens on bacteria trigger inflammatory cascades, resulting in increased serotonin.
Constipation, leading to bacterial buildup, is a huge issue here. The mere presence of stool in the gut is sufficient to cause serotonin production.
This can become a vicious cycle, as bacteria use serotonin to enhance their virulence through biofilm formation.
Natural laxatives like coffee are helpful for alleviating constipation, as well as ensuring adequate magnesium intake (I prefer glycinate as a supplement).
Keeping consistent sleep/wake/eat times for the circadian rhythm is huge too, the entire gut depends on this.
Digestive enzymes, motility, stomach acid, and antimicrobial peptides coordinate based on the time of day.
So making sure your body knows what time it is is key.
Motility is slowed and fecal load is high in all types of gut problems, even diarrhea.
Serotonin can bind to mast (immune) cells, which release histamine.
It’s been hypothesized that histamine intolerance actually starts in the gut.
This goes both ways, as antihistamines also tend to lower serotonin, and diamine oxidase supplementation (from pork kidney) can also help with gut problems.
Benadryl and famotidine (Pepcid) are two popular OTC choices that can have rapid digestive benefits in part by lowering serotonin.
Any type of fiber can promote serotonin production.
Soluble fiber feeds bacteria, and insoluble fiber acts as an irritating agent.
Food additives can increase gut serotonin.
The short chain fatty acids produced by the microbial fermentation also drive serotonin production.
Low or no fiber diets can CURE many of these problems.
IBS, IBD and diverticulitis patients consistently improve massively from no fiber diets.
Not that you need to avoid fiber for life, but if your gut is highly compromised, it's probably the last thing you want more of.
In severe cases, pharmaceutical antibiotics may be helpful.
You are playing with fire, don't get me wrong, but smart implementation of antibiotics can have some incredible effects.
Personally, I had immense benefit from very low dose tetracyclines and penicillin.
Natural antibacterials can also be beneficial. Some good ones:
‣ Oregano oil
‣ Allicin (garlic/onion)
‣ Mastic gum
‣ Pau D'Arco
‣ Rosemary
‣ Thyme
‣ Wormwood
‣ Camphor
‣ Carrot
‣ Berberine
The antibacterial blends Dysbiocide + FC Cidal or Candibactin-AR + Candibactin-BR have been shown to be equivalent to antibiotics for bacterial issues.
Vitamin A/D/zinc inhibit the key enzyme responsible for serotonin synthesis (TPH1).
All of the fat soluble vitamins also have direct antimicrobial properties.
K2 is a huge one for me.
Of course, all stems from poor metabolism and stress.
Bacterial issues can especially arise when gut metabolism is suboptimal. In this case, oxygen is not used for energy, and instead leaks into the gut.
Higher oxygen environments foster the growth of more and more pathogenic gut bacteria, and this is seen in every GI disease.
So the primary mitochondrial nutrients, B1/2/3/5/6/7, copper, iron, sulfur, electrolytes and thyroid hormone, are also critical to master.
A lack of allopregnanolone (a metabolite of pregnenolone/progesterone) and/or DHT, is known to induce gut problems via serotonin increase.
Allopregnanolone reverses this effect, and administering pregnenolone / progesterone can work wonders as well.
Of course, there are also antiserotonin drugs.
Cyproheptadine played an absolutely huge role in my recovery from debilitating gut problems.
Some other antiserotonin agents are L-Lysine, methysergide, metergoline, LSD, ketanserin, and ondansetron. [NOT MEDICAL ADVICE]
The serotonin transporter relies on sodium to pull serotonin into cells and deactivate it, and low salt diets increase serotonin.
Lower salt diets also impair insulin sensitivity and can raise cortisol.
The cortisol precursor, CRH, also increases gut inflammation and serotonin. Stress kills.
Pregnenolone / progesterone are our endogenous anti-CRH steroids.
Fasting also increases serotonin levels in the gut and systemically.
Doesn't that all sound so happy?
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