10 potent tools to 10x your dopamine levels THREAD 🧵
NootBro@nootropicguy
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Jan 10, 2025
~4 min read
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10 potent tools to 10x your dopamine levels
THREAD 🧵
THREAD 🧵
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DISCLAIMER: This is not medical advice. I am not a doctor. Consult a doctor before using any supplement or drug. Do your own research on the risks of each supplement or drug prior to using.
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Dopamine is the #1 key to success
It's essential for:
- motivation/willpower
- attention/focus
Strategically enhancing dopamine while simultaneously using it in a productive manner sets you up to win big
With that, let's dive right into it...
It's essential for:
- motivation/willpower
- attention/focus
Strategically enhancing dopamine while simultaneously using it in a productive manner sets you up to win big
With that, let's dive right into it...
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1) SAFFRON
FIrst up is Saffron
Everyone knows about Saffron as a culinary spice
But few understand it's cognitive-enhancing power
Here's how it works:
FIrst up is Saffron
Everyone knows about Saffron as a culinary spice
But few understand it's cognitive-enhancing power
Here's how it works:
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Saffron contains dopaminergic bioactives such as crocin that:
- Inhibit Dopamine Reuptake
- Inhibit Noradrenaline Reuptake
- Block Serotonin 5-HT2C Receptors
And according to a human study out of Iran, Saffron is as effective as Ritalin for treating ADHD
Let that sink in...
- Inhibit Dopamine Reuptake
- Inhibit Noradrenaline Reuptake
- Block Serotonin 5-HT2C Receptors
And according to a human study out of Iran, Saffron is as effective as Ritalin for treating ADHD
Let that sink in...
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From my experience, extracts rich in crocin such as the ones below are much more stimulating
I've been taking 60mg daily as of late and haven't looked back
lddy.no/1eqcp
I've been taking 60mg daily as of late and haven't looked back
lddy.no/1eqcp
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2) CATUABA BARK
When I tried Catuaba for the first time two years ago, I blown away by how potent it was
It was noticeably stimulating without the typical stimulant jitters
And when you look at the science behind it, it makes total sense
When I tried Catuaba for the first time two years ago, I blown away by how potent it was
It was noticeably stimulating without the typical stimulant jitters
And when you look at the science behind it, it makes total sense
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Catuaba:
- Increases dopamine release
- Inhibits dopamine reuptake
- Prevents dopamine breakdown (mild)
While Trichilia catigua is considered “true Catuaba..."
Erythroxylum catuaba is very similar and is just as potent in my experience
If not more potent...
- Increases dopamine release
- Inhibits dopamine reuptake
- Prevents dopamine breakdown (mild)
While Trichilia catigua is considered “true Catuaba..."
Erythroxylum catuaba is very similar and is just as potent in my experience
If not more potent...
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3) BROMANTANE
Bromantane is my favorite compound on this entire list
Here's why:
Bromantane boosts dopamine levels...
But unlike something like Adderall, it does so without addiction, tolerance, or withdrawal
Read that again...
Bromantane is my favorite compound on this entire list
Here's why:
Bromantane boosts dopamine levels...
But unlike something like Adderall, it does so without addiction, tolerance, or withdrawal
Read that again...
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How?
1) Increases DA synthesis (TH/AAAD)
2) Increases DA sensitivity (BDNF/GDNF)
It has a noticeable acute effect that
a) builds with consistent use
b) synergizes with other dopaminergics
While it's safe overall IMO, it’s not a supplement nor is it an approved drug in the USA
1) Increases DA synthesis (TH/AAAD)
2) Increases DA sensitivity (BDNF/GDNF)
It has a noticeable acute effect that
a) builds with consistent use
b) synergizes with other dopaminergics
While it's safe overall IMO, it’s not a supplement nor is it an approved drug in the USA
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4) CORDYCEPS
Cordyceps is infamously known as “Himalayan Viagra”
It reliably increases testosterone via bioactives that are analogous in structure to luteinizing hormone
Testosterone indirectly boosts dopamine via epigenetic mechanisms, but Cordyceps doesn't stop there...
Cordyceps is infamously known as “Himalayan Viagra”
It reliably increases testosterone via bioactives that are analogous in structure to luteinizing hormone
Testosterone indirectly boosts dopamine via epigenetic mechanisms, but Cordyceps doesn't stop there...
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Cordyceps is not only "Himalayan Viagra"
It's also "Herbal Bromantane"
It shares 2 key benefits with Bromantane:
1) Boosts dopamine synthesis by upregulating tyrosine hydroxylase
2) Enhances endurance & oxygen utilization
To be honest, Bromantane is much more potent tho
It's also "Herbal Bromantane"
It shares 2 key benefits with Bromantane:
1) Boosts dopamine synthesis by upregulating tyrosine hydroxylase
2) Enhances endurance & oxygen utilization
To be honest, Bromantane is much more potent tho
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5) RHODIOLA ROSEA
Cordyceps isn’t the only dopamine-boosting adaptogen
As it turns out, Rhodiola Rosea also powerfully boosts dopamine, in more way than one
- Blocks DA breakdown (COMTi/MAOi)
- Enhances dopaminergic neurogenesis
- Increases BBB permeability to dopamine
Cordyceps isn’t the only dopamine-boosting adaptogen
As it turns out, Rhodiola Rosea also powerfully boosts dopamine, in more way than one
- Blocks DA breakdown (COMTi/MAOi)
- Enhances dopaminergic neurogenesis
- Increases BBB permeability to dopamine
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This may surprise some of you who consider it a calming, anti-stress herb
But extracts that are rich in SALIDROSIDE (rather than rosavin) are much more stimulating in my experience
I've been using this for 8 months and it's been a game-changer
amazon.com/dp/B0751HBW2F?…
But extracts that are rich in SALIDROSIDE (rather than rosavin) are much more stimulating in my experience
I've been using this for 8 months and it's been a game-changer
amazon.com/dp/B0751HBW2F?…
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6) ISTRADEFYLLINE
Like Bromantane, this one is technically a pharmaceutical drug
It's used in Parkinson's Disease where dopamine levels are low due to neurodegeneration
It indirectly increases dopamine (D2 receptor) signaling via blocking the adenosine A2A receptor
Like Bromantane, this one is technically a pharmaceutical drug
It's used in Parkinson's Disease where dopamine levels are low due to neurodegeneration
It indirectly increases dopamine (D2 receptor) signaling via blocking the adenosine A2A receptor
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Because A2A receptors form heteromeric complexes with dopamine D2 receptors....
Blocking A2A increases D2 signaling
This improves certain Parkinson's symptoms & may help depression
And unlike caffeine, it shouldn't induce cardiovascular side effects or dependence
Blocking A2A increases D2 signaling
This improves certain Parkinson's symptoms & may help depression
And unlike caffeine, it shouldn't induce cardiovascular side effects or dependence
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7) VIGNATEX
Vignatex is an innovative combination of
a) mung bean
b) passionflower
These 2, especially mung bean, contain compounds that slow the breakdown of dopamine (via MAO inhibition)
Vignatex is an innovative combination of
a) mung bean
b) passionflower
These 2, especially mung bean, contain compounds that slow the breakdown of dopamine (via MAO inhibition)
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While Passionflower also inhibits MAO, it mainly works to smooth out any potential jitters via enhancing GABAergic activity
To be honest, I personally wouldn't use Vignatex for nootropic purposes
But it may potentially be useful for lowering prolactin or Restless Leg Syndrome
To be honest, I personally wouldn't use Vignatex for nootropic purposes
But it may potentially be useful for lowering prolactin or Restless Leg Syndrome
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8 + 9) SABROXY & POLYGALA
Sabroxy & Polygala are 2 of the heavy hitters on this list
And Notable Focus contains both
Sabroxy boosts dopamine via its key bioactive Oroxylin A, a potent dopamine reuptake inhibitor
Polygala works similarly via yuanzhi-1 & also inhibits MAO
Sabroxy & Polygala are 2 of the heavy hitters on this list
And Notable Focus contains both
Sabroxy boosts dopamine via its key bioactive Oroxylin A, a potent dopamine reuptake inhibitor
Polygala works similarly via yuanzhi-1 & also inhibits MAO
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Because I formulated Notable, I'm biased...
But I strongly believe this is one of the most potent dopamine-boosting supplements on the market
I recommend 2-4 capsules, or 1 capsule dumped & held under tongue
Very synergistic w/ caffeine
meetnotable.com
But I strongly believe this is one of the most potent dopamine-boosting supplements on the market
I recommend 2-4 capsules, or 1 capsule dumped & held under tongue
Very synergistic w/ caffeine
meetnotable.com
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10) PHENYLPIRACETAM
Phenylpiracetam was everyone's favorite nootropic
Until it recently got banned by the FDA
It's also banned in sports by WADA
(Bromantane too)
That how you know it works 😉
Phenylpiracetam was everyone's favorite nootropic
Until it recently got banned by the FDA
It's also banned in sports by WADA
(Bromantane too)
That how you know it works 😉
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Unlike other racetams, it supercharges dopamine by blocking dopamine reuptake
It also:
- Boosts neurogenesis via BDNF
- Boosts alpha- and beta-wave activity
Depending on ur location, you can buy from Cosmic Nootropic, but I haven't used theirs yet so YMMV
10% off w/ NOOTBRO
It also:
- Boosts neurogenesis via BDNF
- Boosts alpha- and beta-wave activity
Depending on ur location, you can buy from Cosmic Nootropic, but I haven't used theirs yet so YMMV
10% off w/ NOOTBRO
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That's the thread
There are many others, including a novel one I am adding to Notable V2
I'll be detailing this one & even more powerful ones in my newsletter in the days to come
You won't want to miss this 👇
nootbro.substack.com
There are many others, including a novel one I am adding to Notable V2
I'll be detailing this one & even more powerful ones in my newsletter in the days to come
You won't want to miss this 👇
nootbro.substack.com
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