Researchers have called it the guardian of the gut.

It is a godsend for IBS, Crohn’s, Ulcerative Colitis and even colon cancer.

Why BUTYRATE might be your key optimal digestion + gut health:

You are looking at a dramatic improvement in colon tumors by using butyrate in animals.

Butyrate:

⬩KILLS colon cancer cells
⬩STOPS metastasis
⬩SHRINKS tumors

Cancer is a metabolic disease, and butyrate is the primary metabolic fuel of the colon.

Butyrate cuts colon cancer tumors by over 80%

Improves:

⬩Survival
⬩Histology
⬩Gut function

In colon cancer.

Butyrate works here by improving bacterial composition and directly reducing inflammation,

people with colon cancer have lower butyrate in the gut.

Butyrate is highly effective for IBS.

At 300 mg a day, sodium butyrate improved:

⬩ Abdominal pain
⬩ Urge sensation
⬩ Stool consistency
⬩ Constipation

After 12 weeks.

It is the single most important metabolite in the colon, regulating nearly every function of gut health.

Another study showed in IBS patients showed that butyrate improved:

⬩Abdominal pain
⬩Flatulence
⬩Diarrhea
⬩Constipation
⬩Urgent pressure for stool
⬩Nausea
⬩Vomiting
⬩QUALITY OF LIFE

So, essentially every symptom you can think of.

Butyrate induces remission in Crohn's disease.

4g for 4 weeks:

• Nearly reversed visible pathology in the colon
• Reduced markers of inflammation

by improving gut bioenergetics.

Butyrate has profound inflammation reducing properties that make it incredible for IBDs.

Butyrate therapeutic for Ulcerative Colitis, improves sleep.

600 mg per day, improvements in:

⬩ALL symptoms
⬩ALL markers of inflammation
⬩Sleep quality

Butyrate regulates the circadian rhythm by increasing circadian clock genes expression,

this is HUGE for digestion.

The circadian rhythm is critical for gut health, as it reduces:

⬩Pathogenic bacteria
⬩Intestinal permeability
⬩Inflammation

& so more.

I’ve written on the importance of circadian rhythms and gut health here:

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Butyrate levels are higher when inflammatory gut problems subside.

The metabolism of butyrate and glutamine are both LOW in these states.

Gut inflammation is driven by poor gut metabolism,

But supplementing back butyrate & glutamine have shown a ton of benefit.

I’ve written on the benefits of taking glutamine here:

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Butyrate reduces diverticulitis / diverticulosis.

At 300 mg per day, it was shown to reduce these serious conditions.

Butyrate supports the structure of the gut by increasing:

⬩Tight junction proteins
⬩Mucus production
⬩Cell migration
⬩Stem cell differentiation

Butyrate prevents food allergies.

Animals given butyrate were protected from peanut allergies, as they had:

⬩Less anaphylaxis
⬩Lower IgE
⬩More “tolerant” / anti-inflammatory immune cells
⬩Reduced mast cell degranulation

Allergies begin in the gut - butyrate can help.

Butyrate improves gut motility.

Oral butyrate supplementation was shown to increase the proportion of neurons in the gut that produce acetylcholine.

Acetylcholine is the primary regulator of gut motility, and low gut acetylcholine can lead to diarrhea or constipation.

Butyrate improves gut bacterial balance.

Butyrate is a metabolite of “good” bacteria, but it also stabilizes the gut environment to where more butyrate producing microbes proliferate.

Thus, it is the inverse of dependency - it should set your gut up for a healthier future.

How butyrate improves gut health:

1. ENERGY

Butyrate is the primary source of fuel for the cells lining the large intestine.

This maintains all of their functions - energy metabolism is what allows cells to fulfill their proper phenotype.

This is also important for butyrate’s anti-cancer properties.

Butyrate metabolism in the colon requires lots of oxygen, and when there isn’t enough butyrate metabolism, the oxygen leaks into the gut.

Pathogenic bacteria thrive in this oxygen rich environment, meaning that the metabolism ultimately determines the health of your gut bacteria.

2. Anti-inflammatory

Short chain fatty acids like butyrate have multiple ways of calming inflammation, especially in the gut.

First, it inhibits the nuclear translocation of the master inflammatory gene regulator, NF-κB. This is ubiquitously elevated in digestive inflammatory conditions.

Second, it halts the primary white blood cells, neutrophils, from being overactive.

It also decreases mast cell degranulation, which stops a rise in histamine, serotonin, among other inflammatory mediators commonly elevated in gut inflammation.

Finally, butyrate is perhaps our primary endogenous inhibitor of histone deacetylases.

Histone deacetylase inhibitors have been developed by pharma for their anti-cancer and anti-inflammatory properties. More on this later.

3. Mucus

The gut mucus layer is absolutely vital. It acts as a protective layer to prevent pathogens and food residue from coming into contact with the cells of the colon, which causes inflammation.

It also houses various antimicrobial factors, such as sIgA and antimicrobial peptides.

This mucus layer becomes depleted with gut symptoms, especially in things like inflammatory bowel disease.

Butyrate fuels the secretion of mucus.

4. Antimicrobial peptides

I mentioned this previously but not only does butyrate directly improve the gut’s structure and energy, but it actually improves the bacterial composition as well.

It increases the production of “good” bacteria which helps to eliminate pathogens.

In this way it acts like a pre or probiotic.

Additionally, it supports the production of antimicrobial peptides, our body’s own antibiotics.

Considering the fact that so many gut issues are driven by bacterial overgrowth, this is absolutely huge.

5. Motility

Finally, butyrate supports motility as I mentioned earlier.

It’s hard to overstate how important this is for gut health, impaired motility underlies just about everything that goes wrong digestive wise.

People with IBS have impaired motility and higher fecal loads.

Symptoms like nausea, bloating, gas, improper bowel habits, etc are all driven by poor motility.

You will not fix your gut health without addressing this first.

This is an excellent butyrate product.

This link will give you 15% off.

I think starting with one capsule of sodium butyrate daily is a good strategy.

That will give you 600 mg, which is a pretty good dose.

bodybio.com/products/butyr…

Butyrate is awesome, but it might not fully do the job for you.

If YOU want personalized help from us optimizing your health, click where it says “schedule a free call” here: prism.miami

I've touched more on the importance of histone acetylation / deacetylation here.

Vinegar is very similar to butyrate as it contains acetate, a closely related molecule:

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Some further reading of interest

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