Taking 5 mg of melatonin raised growth hormone by 157% within 40...
Siim Land@siimland
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Sep 23, 2025
1
Taking 5 mg of melatonin raised growth hormone by 157% within 40 minutes.
When resistance training was performed 60 minutes after ingestion, GH rose again — reaching a 132% increase by the 83rd minute.
Exercise alone (placebo group) likely increased GH by ~50–70%, though exact figures were not reported.
A lower dose of 0.5 mg melatonin led to a 106% increase in GH post-exercise, indicating melatonin's role
Study: PMID: 17956623
When resistance training was performed 60 minutes after ingestion, GH rose again — reaching a 132% increase by the 83rd minute.
Exercise alone (placebo group) likely increased GH by ~50–70%, though exact figures were not reported.
A lower dose of 0.5 mg melatonin led to a 106% increase in GH post-exercise, indicating melatonin's role
Study: PMID: 17956623
2
While growth hormone's role in muscle growth or performance is overrated, it might have some effects on body composition and recovery.
Melatonin boosts GH by suppressing somatostatin, enabling GH release even during the day, independent of sleep.
While exercise alone raises GH, it does so to a lesser extent — but it appears to extend the GH response when combined with melatonin, preventing the typical decline after its peak.
Melatonin boosts GH by suppressing somatostatin, enabling GH release even during the day, independent of sleep.
While exercise alone raises GH, it does so to a lesser extent — but it appears to extend the GH response when combined with melatonin, preventing the typical decline after its peak.
3
Neither melatonin supplementation (0.5 or 5.0 mg) nor resistance exercise had a significant effect on serum IGF-1 levels during the 2-hour study window
That's because the rise of IGF-1 from growth hormone takes several hours - up to 8-24 hours
Thus, it's biologically plausible that the melatonin intervention resulted in higher IGF-1 in 8 hours, although it wasn't measured in this study
That's because the rise of IGF-1 from growth hormone takes several hours - up to 8-24 hours
Thus, it's biologically plausible that the melatonin intervention resulted in higher IGF-1 in 8 hours, although it wasn't measured in this study
