Circadian clock dysfunction affects virtually all the hallmarks of...

Circadian clock dysfunction affects virtually all the hallmarks of aging:
- chronic inflammation
- mitochondrial dysfunction
- loss of autophagy
- gut dysbiosis
- cell senescence
- telomere shortening

Graph: PMID: 36583849

With aging, circadian clocks lose robustness:

- Reduced amplitude of rhythms (weaker hormone and gene oscillations)
- Phase advance (earlier sleep/wake times)
- Impaired synchronization (due to weaker light sensitivity, sedentary lifestyle, irregular habits)

Graph: PMID: 36583849

I just had a podcast with @GregPotterPhD who is a circadian rhythm expert

We break down how circadian clock dysfunction contributes to aging and how you can maintain better circadian clock function with age

youtu.be/eu4IP8VO80Y