Chronic fatigue can be substantially improved with a cheap, over the counter supplement, according to several recent studies.
(π§΅1/6)
Coenzyme Q10 (CoQ10) is a molecule ubiquitous in our bodies, and in some animal foods like beef heart.
Research has shown that plasma levels of CoQ10 are markedly lower in those with:
β Depression
β Chronic fatigue syndrome
and these levels predict the severity of these conditions.
In other words, the lower your CoQ10, the more depressed and fatigued you'll be.
(2/6)
Research has shown that plasma levels of CoQ10 are markedly lower in those with:
β Depression
β Chronic fatigue syndrome
and these levels predict the severity of these conditions.
In other words, the lower your CoQ10, the more depressed and fatigued you'll be.
(2/6)
But supplementing it back has shown the ability to reduce fatigue.
Here, patients with heart failure experiencing fatigue were either given 60 mg of liposomal CoQ10 or placebo.
Those receiving the CoQ had a 20% decline in fatigue symptoms.
(3/6)
Here, patients with heart failure experiencing fatigue were either given 60 mg of liposomal CoQ10 or placebo.
Those receiving the CoQ had a 20% decline in fatigue symptoms.
(3/6)
Other studies have shown similar results.
One of the most notable was using 300 mg in fibromyalgia patients, and they experienced benefits across the board:
β Total symptom score: β 53% decrease
β Pain: β 47% decrease
β Fatigue: β 47% decrease
β Morning tiredness: β 56% decrease
β Stiffness: β 47% decrease
β Anxiety: β 43% decrease
β Depression: β 46% decrease
within 40 days.
(4/6)
One of the most notable was using 300 mg in fibromyalgia patients, and they experienced benefits across the board:
β Total symptom score: β 53% decrease
β Pain: β 47% decrease
β Fatigue: β 47% decrease
β Morning tiredness: β 56% decrease
β Stiffness: β 47% decrease
β Anxiety: β 43% decrease
β Depression: β 46% decrease
within 40 days.
(4/6)
CoQ10 also induced several favorable changes on the molecular level.
Inflammatory mediators:
β IL-6: β 50% decrease
β IL-8: β 50% decrease
β TNF-Ξ±: β 35% decrease
Mitochondria & antioxidants:
β PGC-1Ξ±: β 40% increase - mitochondrial creation factor
β TFAM: β 40% increase - mitochondrial DNA control
β NRF1: β 35% increase - master antioxidant switch
β SOD1: β 30% increase - antioxidant enzyme
β SOD2: β 35% increase - mitochondrial antioxidant
β AMPK: β 60% increase - energy burning master enzyme
(5/6)
Inflammatory mediators:
β IL-6: β 50% decrease
β IL-8: β 50% decrease
β TNF-Ξ±: β 35% decrease
Mitochondria & antioxidants:
β PGC-1Ξ±: β 40% increase - mitochondrial creation factor
β TFAM: β 40% increase - mitochondrial DNA control
β NRF1: β 35% increase - master antioxidant switch
β SOD1: β 30% increase - antioxidant enzyme
β SOD2: β 35% increase - mitochondrial antioxidant
β AMPK: β 60% increase - energy burning master enzyme
(5/6)
The power of CoQ10 is highly unique:
CoQ10 is redox active - it accepts electrons.
This property is very important within our cells, since:
β Mitochondria transfer electrons to produce energy
β Free radicals need somewhere to dump electrons to prevent damaging the cell
CoQ10 plugs into both roles - serving as a lipid antioxidant, helping to:
β Spare vitamin E, C, glutathione
β Prevent cell death / lipid peroxidation
β Curb excessive free radical / ROS accumulation, which can trigger inflammation / alter cell signaling
While also being required in the mitochondria's energy production apparatus.
β Impaired mitochondrial metabolism
β Oxidative stress (excessive free radical accumulation / damage)
β Inflammation
are all key drivers of symptoms of fatigue.
(6/6)
CoQ10 is redox active - it accepts electrons.
This property is very important within our cells, since:
β Mitochondria transfer electrons to produce energy
β Free radicals need somewhere to dump electrons to prevent damaging the cell
CoQ10 plugs into both roles - serving as a lipid antioxidant, helping to:
β Spare vitamin E, C, glutathione
β Prevent cell death / lipid peroxidation
β Curb excessive free radical / ROS accumulation, which can trigger inflammation / alter cell signaling
While also being required in the mitochondria's energy production apparatus.
β Impaired mitochondrial metabolism
β Oxidative stress (excessive free radical accumulation / damage)
β Inflammation
are all key drivers of symptoms of fatigue.
(6/6)
I'm a big fan of this brand which sells beef heart crisps, super high in CoQ10.
grazly.co/ANALYZEOPTIMIZE
grazly.co/ANALYZEOPTIMIZE
CoQ10 is awesome, but it might not be the only thing you need to fully reach optimal health.
You'll want to go all in and have a tailored plan for your specific needs. We can help you with that.
Book a free call with us here and we'll get you started:
go.prism.miami/consultation
You'll want to go all in and have a tailored plan for your specific needs. We can help you with that.
Book a free call with us here and we'll get you started:
go.prism.miami/consultation
Here's a meta study of the trials of CoQ10/fatigue: frontiersin.org/journals/pharmβ¦
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