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To downgrade the importance of melanin, however, is to overlook the significant differences between brain melanin (neuromelanin) and skin melanin properties. The clinician must realize that neuromelanin does not correlate clearly with one’s skin melanin, in either known formative mechanisms, gross amounts, or major functions. While the internal molecular arrangements and diffuse interconnections of one’s neuromelanin-monoamine network may vary uniquely with each individual, such variations in one’sneuromelanin do not correlate (in any obvious way) with one’s skin color (whether white, red, yellow, black, brown, or albino). They do correlate with their magnetic footprint, CMRO2, and OPN5 function. This is how you hold onto to your endogenous melanin via the MITF-AMPAR pathways.
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