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How to lower or block serotonin.🧵
Aspirin (ASA) lowers serotonin. "Aspirin treatment (1, 2, or 4 mg/kg/day) increased survival rate, and attenuated right ventricular hypertrophy and pulmonary arteriole proliferation in an MCT-induced PAH rat model. The effects of ASA may be related to the reduction of plasma 5-HT."
L-theanine lowers brain serotonin.
Correcting a thiamine deficiency lowers brain serotonin.
Glycine and taurine likely lower brain serotonin.
Ginger is a serotonin receptor antagonist (blocker) that reduces stress-induced increases in serotonin (alcohol withdrawal). <a target="_blank" href="https://lowmegatron.substack.com/p/how-serotonin-made-you-fat-cold-and" color="blue">lowmegatron.substack.com/p/how-serotoni…</a>
[6]-Gingerol is a compound in ginger. It can reduce gut and brain serotonin by lowering the relevant enzymes (TPH1 and 2). It also increases MAO-A, which breaks down serotonin. “[6]-gingerol significantly reduced the noted increases in TPH-1 and TPH-2 levels.”
The parathyroid hormone may (in vitro study) cause the release of serotonin and histamine from mast cells. <a target="_blank" href="https://twitter.com/lowmegatron/status/1905680169068540162" color="blue">x.com/lowmegatron/st…</a>
Hypothyroidism increases brain serotonin (5-HT). <a target="_blank" href="https://twitter.com/lowmegatron/status/1897692536606466293" color="blue">x.com/lowmegatron/st…</a>
The anti-histamine cyproheptadine is also a serotonin antagonist (blocker). It has been trialed with success in serotonergic conditions like IBS, cancer (in combination), schizophrenia (comb), liver cancer (comb), autism (comb), and depression (suppressible dexamethasone tests). Cyproheptadine is used for the emergency treatment of serotonin syndrome, a potentially fatal, often drug-induced condition caused by excessive serotonin levels in the body.
Positive ions increase blood serotonin (5-HT). "Negative ions in the air seem to help the lungs to destroy the serotonin in an oxidative process." Ray Peat This can partly explain the beneficial effects of waterfalls and the ocean on “mental” health. <a target="_blank" href="https://twitter.com/lowmegatron/status/1876389117434511412" color="blue">x.com/lowmegatron/st…</a>
<a target="_blank" href="https://x.com/cyclos17/status/1882209515703255171" color="blue">x.com/cyclos17/statu…</a>
Vitamin E can lower brain serotonin.
The anti-nausea drug Ondansetron is a serotonin blocker that is useful in IBS-D. “Ondansetron relieves some of the most intrusive symptoms of IBS-D, namely loose stools, frequency and urgency.”
Magnesium deficiency elevates brain serotonin. Increasing magnesium decreases the likelihood of seizures.
DHEA might lower serotonin by reducing the serotonin-producing enzyme TPH (tryptophan hydroxylase), which is elevated by stress. High doses of DHEA, greater than 5 mg, especially orally, can be estrogenic.
Serotonin, BCAAs, athletic performance, tryptophan, and cancer. From Serotonin, depression, and aggression: The problem of brain energy by Ray Peat "Large neutral amino acids compete with tryptophan for entry into cells, the branched chain amino acids have some antiserotonin activity, and this could be a justification for their use by athletes, since tryptophan and serotonin decrease glycogen stores and reduce endurance. The only amino acid that has ever been found to be carcinogenic is tryptophan. Its ability to mimic estrogen in promoting the release of prolactin is probably responsible. A large carbohydrate meal increases the ratio of tryptophan to the competing amino acids, and it has been proposed that this can shift the body's balance toward increased serotonin. In an animal study, bromocriptine, which shifts the balance away from serotonin, reduced obesity and insulin and free fatty acids, and improved glucose tolerance."
Linoleic acid, which is abundant in seed oils, pork, and poultry fat, makes platelets release serotonin into the blood.
The amino acid lysine is a serotonin blocker that reduces serotonin-induced diarrhea and anxiety. Some people report these benefits at 500 mg 2-3 times daily. “l-Lysine inhibited binding of serotonin to the 5-HT4 receptor.” “l-Lysine blocked serotonin-induced contractions of an isolated guinea pig ileum in vitro.” “Orally applied l-lysine inhibited diarrhea triggered by coadministration of restraint stress and 5-HTP, and significantly blocked anxiety induced by the serotonin 5HT4 receptor agonist in rats in vivo.” “l-Lysine may be a partial serotonin 5-HT4 receptor antagonist and suppresses 5-HT4 receptor-mediated intestinal pathologies and anxiety in rats.” “An increase in nutritional load of l-lysine might be a useful tool in treating stress-induced anxiety and 5-HT-related diarrhea-type intestinal dysfunctions.” The 5-HT4 serotonin receptor system primarily involves gastrointestinal motility and cognitive function. [High doses for extended periods might be immunosuppressive by competing with arginine.]
