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> B1 shots STOP ANXIETY in B1-deficient patients with GAD > The max score (worst) on the scale is 30 > Avg score dropped from 27 to 5 on the anxiety scale (HARS) > Oral high-dose thiamine hcl, or fat-soluble forms, are usually as good as B1 shots 🧵⇓
“Thiamine supplementation significantly improved HARS scores, increased both appetite and general well-being, and reduced fatigue in patients with generalized anxiety disorder. Interestingly, these patients were able to discontinue taking anxiolytic and β-blocker medications.”
“Parental thiamine significantly affects patients with generalized anxiety disorder. Patients completed the Hamilton Anxiety Rating Scale (HARS) before and one week after thiamine treatment (the mean HARS scores were 27.33 and 5.8, respectively).”
Probably via effects on lactate, histamine, and serotonin. <a target="_blank" href="https://twitter.com/1709153215600558080/status/1877786322057801774" color="blue">x.com/17091532156005…</a>
Histamine is a player in panic attacks. Hyperventilation, by lowering CO2, will increase histamine release.
DAO, an enzyme that destroys histamine, may be helpful in panic disorders. <a target="_blank" href="https://twitter.com/1862123067889119232/status/1877682121554227649" color="blue">x.com/18621230678891…</a>
B1 helps lower lactate, and therefore histamine, by its role in pyruvate dehydrogenase. “Within 4 hours of administration of the first dose of thiamine, all patients’ blood lactate concentrations declined and clinical status significantly improved.” [PMCID: PMC10731935]
