you probably never felt as good as you could
that's because your detox system is overwhelmed
it was designed for natural plant toxins while now it's forced to process synthetic chemicals you never evolved with
1/
monday:
detox evolved to neutralize alkaloids, polyphenols, and occasional smoke, not phthalates or bisphenol analogs.
modern exposure is orders of magnitude higher than what you evolved for
3/
detox evolved to neutralize alkaloids, polyphenols, and occasional smoke, not phthalates or bisphenol analogs.
modern exposure is orders of magnitude higher than what you evolved for
3/
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paleolithic blood lead: ~0.03 μg/dL
current “safe” level: 3.5 μg/dL
a 100× increase.
your body just can't function well like this
4/
current “safe” level: 3.5 μg/dL
a 100× increase.
your body just can't function well like this
4/
tuesday:
detox isn’t filtering.
it’s chemical processing:
phase I (oxidation) → phase II (conjugation) → phase III (excretion)
5/
detox isn’t filtering.
it’s chemical processing:
phase I (oxidation) → phase II (conjugation) → phase III (excretion)
5/
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phase I adds reactive handles
phase II tags them with glutathione, sulfate, etc.
phase III gets rid of them via urine, bile, sweat
6/
phase II tags them with glutathione, sulfate, etc.
phase III gets rid of them via urine, bile, sweat
6/
when phase I works better than phase II, you get reactive intermediates
these damage DNA, lipids, mitochondria
imbalanced detox is toxic
7/
these damage DNA, lipids, mitochondria
imbalanced detox is toxic
7/
wednesday:
key interventions:
sulforaphane → activates Nrf2, boosts enzyme production
NAC → supplies cysteine, builds glutathione
sweating → expands elimination routes
8/
key interventions:
sulforaphane → activates Nrf2, boosts enzyme production
NAC → supplies cysteine, builds glutathione
sweating → expands elimination routes
8/
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they work synergistically
sulforaphane induces glutathione-dependent enzymes
NAC raises glutathione levels
together they lead to higher throughput
9/
sulforaphane induces glutathione-dependent enzymes
NAC raises glutathione levels
together they lead to higher throughput
9/
thursday:
juice cleanses are a biochemical trap
they mobilize fat-stored toxins while depriving the liver of amino acids needed to neutralize them
10/
juice cleanses are a biochemical trap
they mobilize fat-stored toxins while depriving the liver of amino acids needed to neutralize them
10/
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“detox symptoms” means that you have intermediates recirculation in your blood
you're not healing, just damaging yourself more
11/
you're not healing, just damaging yourself more
11/
friday:
the ability to detox is not equal
50% lack GSTM1 entirely
estrogen modulates enzyme activity
aging slows phase transitions
12/
the ability to detox is not equal
50% lack GSTM1 entirely
estrogen modulates enzyme activity
aging slows phase transitions
12/
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your detox response is encoded in your DNA
genetics, hormones, age
this is why “it worked for me” often fails for you
13/
genetics, hormones, age
this is why “it worked for me” often fails for you
13/
saturday:
best strategy:
reduce input
support output
what you don’t absorb, you don’t need to process
14/
best strategy:
reduce input
support output
what you don’t absorb, you don’t need to process
14/
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switching from plastic to glass drops urinary BPA 60% in 3 days
environmental swaps > most pills
15/
environmental swaps > most pills
15/
detox isn’t a cleanse
it’s maintenance that's boring but essential
support your detox pathways
or live downstream of their collapse
16/
it’s maintenance that's boring but essential
support your detox pathways
or live downstream of their collapse
16/
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