Combining selenium and myo-inositol reduces thyroid antibodies, lowers TSH, and increases thyroid hormones in people with hypothyroidism.

The combination also increased TSH in a hyperthyroid patient - it seems to normalize rather than simply increase thyroid function.

Selenium and Myo-inositol are important for thyroid hormone synthesis, and low levels may predispose to the development of hypothyroidism. People with hypothyroidism have a higher demand for myo-inositol.

Study 1:
“In the present study, we were able to demonstrate that, in subclinical hypothyroidism, patients with autoimmune thyroiditis, treated with Myo-Inositol and selenomethionine, experience a reduction of the increased TSH that selenomethionine supplementation alone was not able to promote. Concomitantly, the concentration of the two autoantibodies declined in both groups.”

Study 2:
“TSH, TPOAb, and TgAb antibody levels were significantly decreased in patients treated... a significant fT3, and fT4, increase, along with an amelioration of their quality of life, was observed. Remarkably, TSH values of the hyperthyroid patient increased from 0.14U/ml up to 1.02U/ml, showing a complete restoration of TSH values at a normal range.”

The amount of these nutrients used in the study is easily achieved through diet, too.

There is 83 μg of selenium in:
2 oz oysters, or
3 large eggs, or
10 oz mushrooms

There is 600 mg of myo-inositol in:
12 oz cantaloupe, or
15 oz orange, or
30 oz mandarin

Levels in orange juice seem to vary a lot, but most I can find are much lower than in fresh fruit.