@louisanicola_: You don’t build endurance in y...
@louisanicola_
7 views
Apr 22, 2026
Advertisement
1
You don’t build endurance in your muscles
You’ve been told endurance lives in your heart, lungs, and legs.
That’s outdated.
A new study in the journal Neuron shows a part of your brain, the VMH, actively programs endurance capacity through SF1 neurons.
These neurons increase activity with training and store a memory of effort.
Your performance ceiling is being set in your brain, not just your body.
Read the thread 🧵
You’ve been told endurance lives in your heart, lungs, and legs.
That’s outdated.
A new study in the journal Neuron shows a part of your brain, the VMH, actively programs endurance capacity through SF1 neurons.
These neurons increase activity with training and store a memory of effort.
Your performance ceiling is being set in your brain, not just your body.
Read the thread 🧵
2
Your brain remembers how hard you train
What matters is not just doing the work. It is how your brain records it.
SF1 neurons became more active over time as training continued. They acted like a biological logbook of effort.
This shifts the model:
- Adaptation is not just physical
- It is encoded neurologically
Your brain is tracking your training load and deciding how much output to allow.
What matters is not just doing the work. It is how your brain records it.
SF1 neurons became more active over time as training continued. They acted like a biological logbook of effort.
This shifts the model:
- Adaptation is not just physical
- It is encoded neurologically
Your brain is tracking your training load and deciding how much output to allow.
3
You can train and still not improve
Here’s the uncomfortable part.
When researchers blocked these neurons, endurance gains disappeared even though the mice still trained.
Same work. No adaptation.
That means:
If the brain signal is disrupted, progress stops.
Plateaus may not be physical limits. They may be failures in how the brain processes and approves adaptation.
Here’s the uncomfortable part.
When researchers blocked these neurons, endurance gains disappeared even though the mice still trained.
Same work. No adaptation.
That means:
If the brain signal is disrupted, progress stops.
Plateaus may not be physical limits. They may be failures in how the brain processes and approves adaptation.
4
The limit is not your body
When scientists increased activity in these neurons, endurance kept improving beyond the normal plateau.
No typical ceiling.
This suggests most limits are protective controls set by the brain, not hard biological barriers.
For elite performers, this is critical:
Your system may be capable of more, but your brain is holding the line.
When scientists increased activity in these neurons, endurance kept improving beyond the normal plateau.
No typical ceiling.
This suggests most limits are protective controls set by the brain, not hard biological barriers.
For elite performers, this is critical:
Your system may be capable of more, but your brain is holding the line.
5
The real leverage is coming
The biggest implication is not performance. It is replication.
If these neurons can be targeted, we could reproduce key benefits of exercise without movement.
This has massive implications for:
- Injury recovery
- Longevity
- High output individuals with limited time
The edge will go to those who understand this early.
The biggest implication is not performance. It is replication.
If these neurons can be targeted, we could reproduce key benefits of exercise without movement.
This has massive implications for:
- Injury recovery
- Longevity
- High output individuals with limited time
The edge will go to those who understand this early.