@aestheticprimal: There’s nothing with a more ne...

There’s nothing with a more neurotoxic profile and a dimming effect on the soul like viewing yourself as a loser has.

viewing yourself as a loser actually has a scientific term → ‘social defeat stress’

you essentially view yourself as a victim to your external environment (lack of control equates to learned helplessness) and at the bottom of the social hierarchy.

This feeling of not being in control of situations, or lacking a strong future vision, weakens activity in the prefrontal lobes (mainly mPFC, vmPFC and dlPFC).

These prefrontal cortexes normally have an inhibitory effect on the Amygdala, but when this inhibition fades due to negative self-talk and surrender to external environment, it causes the gut-microbiome its alpha-diversity to decrease through HPA axis activation.

result?

reduced SCFA production, with Butyrate in particular.

Butyrate is crucial for:

- HDAC inhibition (intelligence, memory, focus, motivation)
- androgen receptor expression
- reducing estrogen receptor expression through hyperacetylation
- increasing natural Testosterone production through the HPG
- thyroid hormone uptake

Back in 2022, a bunch of researchers showcased how they were able to completely alter the social dynamic between two mice by simply altering their gut-microbiome through antibiotics, targeting C. Butyricum in particular (one of the main bacteria that produces Butyrate)

The researchers could turn an ‘alpha’ mouse into a ‘beta’ mouse, making it subordinate to the mouse that was previously ‘beta’ in the social dynamic.

It was found that recolonization of the gut-microbiome of said mouse that ‘turned beta’ with C. Butyricum could restore that mouse’s status, and make him ‘alpha’ again.

The researchers thought this was because of the huge role that SCFA’s, with butyrate in particular, play in activity of the prefrontal cortex (mPFC, vmPFC and dlPFC) due to Butyrate its function as HDACi.

With insufficient SCFA/Butyrate levels, it’s almost guaranteed that the function of the prefrontal cortex is going to be impaired in some way.

Results:

- less discipline
- lack of willpower
- reduced goal-achieving capabilities
- surrender to reptile brain (prefrontal cortex exerts inhibitory control over these)
- ADHD-like behavior
- excess rumination of thoughts/overthinking (negative spiral)

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mPFC activity is the most accurate biomarker to predict spot in the social hierarchy

high mPFC activity is endlessly more correlated with being 'alpha' than Testosterone ng/dL levels

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The prefrontal cortex is extremely active when choosing non-pleasurable things for long-term gain over short term gratification.

strong willpower, discipline and goal-achieving capabilities are the symptoms of a highly developed and active mPFC, vmPFC and dlPFC.

and the gut-microbiome is arguably the biggest influence on these brain regions after mindset.

this is why ‘alpha’ mice became ‘beta’ after their gut-microbiomes were attacked (something currently happening to 99% of people through processed foods and silicone dioxide-filled supplements)

your gut-microbiome, almost acts as your second DNA, this is not only because of how tightly it correlates with epigenetic expression by altering histone actetylation/deacetylation, it's way deeper than that.

there's a reason people even experience personality changes from fecal microbiome transplants (not just intestine transplantation)

the contents of the gut shape who you are, and you're quite literally what you eat (no this shouldn't be dumbed down to micronutrient intake only, think of miRNA's that have been shown to alter genomic expression in the organism, and way more than that)

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sciencedirect.com/science/articl…

"yeah white people just had this random mutation that caused them to turn blonde and blue eyed"

how random was this really?

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also quite interesting how anything with a high antioxidant profile tends to potently inhibit mRNA expression of the MC1R

hmmmmm