@bryan_johnson: I paused Metformin.A longevit...
@bryan_johnson
44 views
Oct 14, 2025
1
I paused Metformin.
A longevity staple in my protocol for 5+ years.
But its effects on my body were shocking.
It built up my energy capacity,
but limited my ability to use 90% of it.
Here’s what we found. 🧵
A longevity staple in my protocol for 5+ years.
But its effects on my body were shocking.
It built up my energy capacity,
but limited my ability to use 90% of it.
Here’s what we found. 🧵
2
Our hypothesis:
+ Metformin pushes the cells to recycle, repair, and build new mitochondria (mitochondria are the power plants of the cells).
+ Long-term use kept my cells locked in mitochondria build up mode (I had 3x more mitochondria than normal) but Metformin blocked this optimized mitochondria from being used.
Pausing Metformin unleashed my mitochondria’s full energy potential (spike in power came with more oxidative stress though).
We’re now cycling Metformin, which should give me the best of both worlds, mitochondrial build-up and optimal use.
+ Metformin pushes the cells to recycle, repair, and build new mitochondria (mitochondria are the power plants of the cells).
+ Long-term use kept my cells locked in mitochondria build up mode (I had 3x more mitochondria than normal) but Metformin blocked this optimized mitochondria from being used.
Pausing Metformin unleashed my mitochondria’s full energy potential (spike in power came with more oxidative stress though).
We’re now cycling Metformin, which should give me the best of both worlds, mitochondrial build-up and optimal use.
3
Results so far
7 weeks off Metformin: new peaks in energy output.
My avg cycling power improved 25.6% over my previous personal best.
Energy markers are up across the board:
7 weeks off Metformin: new peaks in energy output.
My avg cycling power improved 25.6% over my previous personal best.
Energy markers are up across the board:
4
We’re now testing a two-phase cycle of Metformin:
